UniProt Accession

 IF2G_RAT; P81795; B0BN96; B2RYH8; Q5BJX8 

Genbank Protein ID

 CH473966; BC091286; BC158736; BC166783 

Genbank Nucleotide ID

 EDL96007.1; AAH91286.1; AAI58737.1; AAI66783.1 

Protein Name

 Eukaryotic translation initiation factor 2 subunit 3 

Protein Synonyms/Alias

 Eukaryotic translation initiation factor 2 subunit gamma; eIF-2-gamma; PP42 

Gene Name

 Eif2s3 

Gene Synonyms/Alias

 Eif2g 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
303	VRPGIVSKDSEGKLM	acetylation	[1]
421	GGRVSAVKADLGKIV	acetylation	[1]
449	ALSRRVEKHWRLIGW	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. 

Sequence Annotation

 NP_BIND 48 55 GTP (By similarity).
 NP_BIND 134 138 GTP (By similarity).
 NP_BIND 190 193 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 22 22 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; GTP-binding; Initiation factor; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 472 AA 

Protein Sequence

Gene Ontology

 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 

Interpro

 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR015256; TIF2_gsu_C.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR009000; Transl_elong_init/rib_B-barrel. 

Pfam

 PF09173; eIF2_C
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2 

SMART

  

PROSITE

  

PRINTS

 PR00315; ELONGATNFCT.