| Tag | Content |
|---|
| CPLM ID | CPLM-010833 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | mRNA-capping enzyme subunit alpha |
Protein Synonyms/Alias | GTP--RNA guanylyltransferase; GTase; mRNA guanylyltransferase |
Gene Name | CEG1 |
Gene Synonyms/Alias | YGL130W; G2853 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 356 | GRIVECAKNQETGAW | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate. |
Sequence Annotation | ACT_SITE 70 70 N6-GMP-lysine intermediate. |
Keyword | 3D-structure; Complete proteome; GTP-binding; mRNA capping; mRNA processing; Nucleotide-binding; Nucleotidyltransferase; Nucleus; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 459 AA |
Protein Sequence | MVLAMESRVA PEIPGLIQPG NVTQDLKMMV CKLLNSPKPT KTFPGSQPVS FQHSDVEEKL 60
LAHDYYVCEK TDGLRVLMFI VINPVTGEQG CFMIDRENNY YLVNGFRFPR LPQKKKEELL 120
ETLQDGTLLD GELVIQTNPM TKLQELRYLM FDCLAINGRC LTQSPTSSRL AHLGKEFFKP 180
YFDLRAAYPN RCTTFPFKIS MKHMDFSYQL VKVAKSLDKL PHLSDGLIFT PVKAPYTAGG 240
KDSLLLKWKP EQENTVDFKL ILDIPMVEDP SLPKDDRNRW YYNYDVKPVF SLYVWQGGAD 300
VNSRLKHFDQ PFDRKEFEIL ERTYRKFAEL SVSDEEWQNL KNLEQPLNGR IVECAKNQET 360
GAWEMLRFRD DKLNGNHTSV VQKVLESIND SVSLEDLEEI VGDIKRCWDE RRANMAGGSG 420
RPLPSQSQNA TLSTSKPVHS QPPSNDKEPK YVDEDDWSD 459 |
Gene Ontology | GO:0031533; C:mRNA cap methyltransferase complex; IGI:SGD. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0004484; F:mRNA guanylyltransferase activity; IMP:SGD. GO:0006370; P:7-methylguanosine mRNA capping; IMP:SGD. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:SGD. |
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