CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011873
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosomal N-lysine methyltransferase 4 
Protein Synonyms/Alias
 SET domain-containing protein 7 
Gene Name
 RKM4 
Gene Synonyms/Alias
 RMS1; SET7; YDR257C; YD9320A.07C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
55KKDETLFKIPRSSVLacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
 Protein lysine methyltransferase that monomethylates 'Lys-55' of 60S ribosomal protein L42 (RPL42A and RPL42B). 
Sequence Annotation
 DOMAIN 25 265 SET.  
Keyword
 Complete proteome; Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 494 AA 
Protein Sequence
MDDFSRDTEN FVCWLKTTAE IEVSPKIEIK DLCCDNQGRA VVATQKIKKD ETLFKIPRSS 60
VLSVTTSQLI KDYPSLKDKF LNETGSWEGL IICILYEMEV LQERSRWAPY FKVWNKPSDM 120
NALIFWDDNE LQLLKPSLVL ERIGKKEAKE MHERIIKSIK QIGGEFSRVA TSFEFDNFAY 180
IASIILSYSF DLEMQDSSVN ENEEEETSEE ELENERYLKS MIPLADMLNA DTSKCNANLT 240
YDSNCLKMVA LRDIEKNEQV YNIYGEHPNS ELLRRYGYVE WDGSKYDFGE VLLENIVEAL 300
KETFETNTEF LDRCIDILRN NANIQEFLEG EEIVLDSYDC YNNGELLPQL ILLVQILTIL 360
CQIPGLCKLD IKAMERQVER IVKKCLQLIE GARATTNCSA TWKRCIMKRL ADYPIKKCVS 420
IEKPSKGNSL TREELRDVMA RRVLKSEIDS LQVCEETIDK NYKVIPDEKL LTNILKRKLT 480
EEEKSSVKRP CVKK 494 
Gene Ontology
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0016279; F:protein-lysine N-methyltransferase activity; IMP:SGD.
 GO:0018026; P:peptidyl-lysine monomethylation; IMP:SGD. 
Interpro
 IPR011383; RuBisCo-cyt_methylase.
 IPR001214; SET_dom. 
Pfam
 PF00856; SET 
SMART
 SM00317; SET 
PROSITE
 PS50280; SET 
PRINTS