CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nardilysin 
Protein Synonyms/Alias
  
Gene Name
 Nrd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
336NGFDAFLKKHGGSDNacetylation[1]
405RPSDANRKEMLFGSLubiquitination[2]
535QQQHYRVKPLHYISWacetylation[3]
535QQQHYRVKPLHYISWsuccinylation[3]
773AQGCLWYKKDNKFKIubiquitination[2]
1034CFDFLRTKQTLGYHVubiquitination[2]
1144EALKSFSKSDLVSWFubiquitination[2]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1229 AA 
Protein Sequence
MLRRVAVAAV CVTGRKLRCE AGRELTALGR IEARGLCEES SKPFPTLTMP GRNKAKSTCS 60
CPDLQPNGQD LGESGRLARL GADESEEEGR SFSNVGDPEI IKSPSDPKQY RYIKLQNGLQ 120
ALLISDLSNV EGKTGNATDE EEEEEEEEEE EDDDDDDDDD DDDEDSGAEI QDDDEEGFDD 180
EEEFDDDDDD EHDDDDLENE ENELEELEER VEARKKTTEK QQSQNLFLLW SKLTDRLWFK 240
SSYSKMSSTL LVETRNLYGV VGAESRSAPV EHLAGWQVEE QQGETDTVLS AAALCVGVGS 300
FADPDDLPGL AHFLEHMVFM GSLKYPDENG FDAFLKKHGG SDNASTDCER TVFQFDVQRK 360
YFKEALDRWA QFFIHPLMIR DAIDREVEAV DSEYQLARPS DANRKEMLFG SLARPGHPMG 420
KFFWGNAETL KHEPKKNNID THARLREFWM RYYSAHYMTL VVQSKETLDT LEKWVTEIFS 480
QIPNNGLPKP NFSHLTDPFD TPAFNKLYRV VPIRKIHALT ITWALPPQQQ HYRVKPLHYI 540
SWLVGHEGKG SILSYLRKKC WALALFGGNG ETGFEQNSTY SVFSISITLT DEGYEHFYEV 600
AHTVFQYLKM LQKLGPEKRV FEEIQKIEDN EFHYQEQTDP VEYVENMCEN MQLYPRQDFL 660
TGDQLLFEYK PEVIAEALNQ LVPQKANLVL LSGANEGRCD LKEKWFGTQY SIEDIENSWT 720
ELWKSNFDLN PDLHLPAENK YIATDFTLKA FDCPETEYPA KIVNTAQGCL WYKKDNKFKI 780
PKAYIRFHLI SPLIQKSAAN VVLFDIFVNI LTHNLAEPAY EADVAQLEYK LVAGEHGLII 840
RVKGFNHKLP LLFQLIIDYL TEFSSTPAVF TMITEQLKKT YFNILIKPET LAKDVRLLIL 900
EYSRWSMIDK YQALMDGLSL DSLLNFVKDF KSQLFVEGLV QGNVTSTESM DFLKYVVDKL 960
NFAPLEREMP VQFQVVELPS GHHLCKVRAL NKGDANSEVT VYYQSGTRSL REYTLMELLV 1020
MHMEEPCFDF LRTKQTLGYH VYPTCRNTSG ILGFSVTVGT QATKYNSETV DKKIEEFLSS 1080
FEEKIENLTE DAFNTQVTAL IKLKECEDTH LGEEVDRNWN EVVTQQYLFD RLAHEIEALK 1140
SFSKSDLVSW FKAHRGPGSK MLSVHVVGYG KYELEEDGAP FGEDSNSREG MQLTYLPPSP 1200
VLAESTTPIT DIRAFTATLS LFPYHKIVK 1229 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008233; F:peptidase activity; ISO:MGI.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR011249; Metalloenz_LuxS/M16.
 IPR011237; Pept_M16_dom.
 IPR011765; Pept_M16_N.
 IPR001431; Pept_M16_Zn_BS.
 IPR007863; Peptidase_M16_C. 
Pfam
 PF00675; Peptidase_M16
 PF05193; Peptidase_M16_C 
SMART
  
PROSITE
 PS00143; INSULINASE 
PRINTS