| Tag | Content |
|---|
| CPLM ID | CPLM-016717 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Translation factor Guf1, mitochondrial |
Protein Synonyms/Alias | Elongation factor 4 homolog; EF-4; GTPase Guf1; Ribosomal back-translocase |
Gene Name | Guf1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 39 | SAAELKEKPDMSRFP | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity). |
Sequence Annotation | NP_BIND 57 64 GTP (By similarity).
NP_BIND 122 126 GTP (By similarity).
NP_BIND 176 179 GTP (By similarity).
CROSSLNK 84 84 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Alternative splicing; Complete proteome; GTP-binding; Hydrolase; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Protein biosynthesis; Reference proteome; Transit peptide; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 651 AA |
Protein Sequence | MWALVGRALA PWAAGARHAA ASEPRAACRL FSAAELKEKP DMSRFPVEDI RNFSIIAHVD 60
HGKSTLADRL LELTGTIDKT KKNKQVLDKL QVERERGITV KAQTASLFYS FGGKQYLLNL 120
IDTPGHVDFS YEVSRSLSAC QGVLLVVDAN EGIQAQTVAN FFLAFEAQLS VIPVINKIDL 180
KNADPERVGK QIEKVFDIPS EECIKISAKL GTNVDSVLQA VIERIPPPKV HRENPLKALV 240
FDSTFDQYRG VIANIALFDG VVSKGDKIVS AHTKKAYEVN EVGILNPNEQ PTHKLYAGQV 300
GFLIAGMKDV TEAQIGDTLY LHNHPVEPLP GFKSAKPMVF AGVYPIDQSE YNNLKSAIEK 360
LTLNDSSVTV HRDSSLALGA GWRLGFLGLL HMEVFNQRLE QEYNASVILT TPTVPYKAVL 420
SSAKLIKEYK EKEITIINPA QFPEKSQVTE YLEPVVLGTV ITPTEYTGKI MALCQARRAI 480
QKNMTFIDEN RVMLKYLFPL NEIVVDFYDS LKSLSSGYAS FDYEDAGYQT AELVKMDILL 540
NGNMVEELVT VVHREKAYTV GKSICERLKE SLPRQLYEIA IQAAVGSKVI ARETVKAYRK 600
NVLAKCYGGD ITRKMKLLKR QSEGKKKLRK IGNIEIPKDA FIKVLKTQPN K 651 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |