CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006483
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate receptor ionotropic, NMDA 1 
Protein Synonyms/Alias
 GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1 
Gene Name
 Grin1 
Gene Synonyms/Alias
 Nmdar1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
913RGALQNQKDTVLPRRubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. 
Sequence Annotation
 REGION 516 518 Glycine binding.
 BINDING 523 523 Glycine.
 BINDING 688 688 Glycine.
 BINDING 732 732 Glycine.
 MOD_RES 889 889 Phosphoserine; by PKC (By similarity).
 MOD_RES 890 890 Phosphoserine; by PKC.
 MOD_RES 896 896 Phosphoserine; by PKC (By similarity).
 MOD_RES 897 897 Phosphoserine; by PKC.
 CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
 CARBOHYD 203 203 N-linked (GlcNAc...) (Potential).
 CARBOHYD 239 239 N-linked (GlcNAc...) (Potential).
 CARBOHYD 276 276 N-linked (GlcNAc...) (Potential).
 CARBOHYD 300 300 N-linked (GlcNAc...) (Potential).
 CARBOHYD 350 350 N-linked (GlcNAc...) (Potential).
 CARBOHYD 368 368 N-linked (GlcNAc...) (Potential).
 CARBOHYD 440 440 N-linked (GlcNAc...) (Potential).
 CARBOHYD 471 471 N-linked (GlcNAc...) (Potential).
 CARBOHYD 491 491 N-linked (GlcNAc...) (Potential).
 DISULFID 79 79 Interchain (By similarity).  
Keyword
 3D-structure; Alternative splicing; Calcium; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Magnesium; Membrane; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 938 AA 
Protein Sequence
MSTMHLLTFA LLFSCSFARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL 60
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG 120
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYNW NHIILLVSDD HEGRAAQKRL 180
ETLLEERESK AEKVLQFDPG TKNVTALLME ARELEARVII LSASEDDAAT VYRAAAMLNM 240
TGSGYVWLVG EREISGNALR YAPDGIIGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN 300
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK 360
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTMSDGTC 420
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA 480
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI 540
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA 600
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP 660
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA 720
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH 780
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH 840
KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT 900
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES 938 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0032590; C:dendrite membrane; IDA:BHF-UCL.
 GO:0060076; C:excitatory synapse; IDA:BHF-UCL.
 GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IDA:RGD.
 GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
 GO:0014069; C:postsynaptic density; IDA:RGD.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0043083; C:synaptic cleft; IDA:RGD.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0043195; C:terminal bouton; IDA:RGD.
 GO:0005262; F:calcium channel activity; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0016595; F:glutamate binding; IDA:UniProtKB.
 GO:0016594; F:glycine binding; IDA:UniProtKB.
 GO:0004972; F:N-methyl-D-aspartate selective glutamate receptor activity; IDA:RGD.
 GO:0042165; F:neurotransmitter binding; IDA:RGD.
 GO:0046982; F:protein heterodimerization activity; IDA:RGD.
 GO:0022843; F:voltage-gated cation channel activity; IMP:RGD.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0071287; P:cellular response to manganese ion; IEP:RGD.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0001661; P:conditioned taste aversion; IEA:Compara.
 GO:0007611; P:learning or memory; TAS:RGD.
 GO:0007616; P:long-term memory; IEA:Compara.
 GO:0060179; P:male mating behavior; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0008355; P:olfactory learning; IEA:Compara.
 GO:0021586; P:pons maturation; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0010942; P:positive regulation of cell death; IDA:RGD.
 GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060134; P:prepulse inhibition; IEA:Compara.
 GO:0018964; P:propylene metabolic process; IEA:Compara.
 GO:0051262; P:protein tetramerization; IDA:RGD.
 GO:0050770; P:regulation of axonogenesis; IEA:Compara.
 GO:0048814; P:regulation of dendrite morphogenesis; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0043576; P:regulation of respiratory gaseous exchange; IEA:Compara.
 GO:0051963; P:regulation of synapse assembly; IEA:Compara.
 GO:0007585; P:respiratory gaseous exchange; IEA:Compara.
 GO:0014075; P:response to amine stimulus; IEP:RGD.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEP:RGD.
 GO:0060992; P:response to fungicide; IEP:RGD.
 GO:0043278; P:response to morphine; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEP:RGD.
 GO:0048511; P:rhythmic process; IDA:RGD.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0035176; P:social behavior; IEA:Compara.
 GO:0001967; P:suckling behavior; IEA:Compara.
 GO:0035249; P:synaptic transmission, glutamatergic; IEA:Compara.
 GO:0008542; P:visual learning; IEA:Compara. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR018882; CaM-bd_C0_NMDA_rcpt_NR1.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt.
 IPR001638; SBP_bac_3. 
Pfam
 PF01094; ANF_receptor
 PF10562; CaM_bdg_C0
 PF00060; Lig_chan
 PF00497; SBP_bac_3 
SMART
 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 
PROSITE
  
PRINTS
 PR00177; NMDARECEPTOR.