CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025721
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transforming growth factor, beta receptor II, isoform CRA_b 
Protein Synonyms/Alias
  
Gene Name
 Tgfbr2 
Gene Synonyms/Alias
 mCG_6467 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
230SPSWESSKPRKLMDFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Kinase; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 592 AA 
Protein Sequence
MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SDVEMEAQKD ASIHLSCNRT IHPLKHFNSD 60
VMASDNGGAV KLPQLCKFCD VRLSTCDNQK SCMSNCSITA ICEKPHEVCV AVWRKNDKNI 120
TLETVCHDPK LTYHGFTLED AASPKCVMKE KKRAGETFFM CACNMEECND YIIFSEEYTT 180
SSPDLLLVII QVTGVSLLPP LGIAIAVIII FYCYRVHRQQ KLSPSWESSK PRKLMDFSDN 240
CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 300
VKIFPYEEYS SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE 360
YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL 420
CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW 480
EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDSVLRDR GRPEIPSFWL NHQGIQIVCE 540
TLTECWDHDP EARLTAQCVA ERFSELEHPE RLSGRSCSQE KIPEDGSLNT TK 592 
Gene Ontology
 GO:0005901; C:caveola; ISO:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0043235; C:receptor complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005539; F:glycosaminoglycan binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:InterPro.
 GO:0005026; F:transforming growth factor beta receptor activity, type II; IEA:InterPro.
 GO:0005024; F:transforming growth factor beta-activated receptor activity; IGI:MGI.
 GO:0032147; P:activation of protein kinase activity; IDA:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0060434; P:bronchus morphogenesis; IMP:MGI.
 GO:0007182; P:common-partner SMAD protein phosphorylation; IEA:Compara.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0007369; P:gastrulation; IMP:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0002088; P:lens development in camera-type eye; IMP:MGI.
 GO:1990086; P:lens fiber cell apoptotic process; IDA:MGI.
 GO:0060463; P:lung lobe morphogenesis; IMP:MGI.
 GO:0060443; P:mammary gland morphogenesis; IMP:MGI.
 GO:0043011; P:myeloid dendritic cell differentiation; IMP:MGI.
 GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IMP:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0002663; P:positive regulation of B cell tolerance induction; IMP:MGI.
 GO:0010634; P:positive regulation of epithelial cell migration; IMP:MGI.
 GO:0051138; P:positive regulation of NK T cell differentiation; IMP:MGI.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Compara.
 GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0002666; P:positive regulation of T cell tolerance induction; IMP:MGI.
 GO:0002651; P:positive regulation of tolerance induction to self antigen; IMP:MGI.
 GO:0006898; P:receptor-mediated endocytosis; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IMP:MGI.
 GO:0070723; P:response to cholesterol; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0007224; P:smoothened signaling pathway; IMP:MGI.
 GO:0060440; P:trachea formation; IMP:MGI.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0042060; P:wound healing; IEA:Compara. 
Interpro
 IPR000333; Activin_II/TGFBeta-II_recpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR017194; Transform_growth_fac-b_typ-2.
 IPR015013; Transforming_GF_b_rcpt_2_ecto. 
Pfam
 PF08917; ecTbetaR2
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS
 PR00653; ACTIVIN2R.