| Tag | Content |
|---|
| CPLM ID | CPLM-011101 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase SKY1 |
Protein Synonyms/Alias | SRPK |
Gene Name | SKY1 |
Gene Synonyms/Alias | YMR216C; YM8261.10C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 84 | VQEDTSSKTEDFSTK | ubiquitination | [1] | | 193 | MKIVRGDKVYTEAAE | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Constitutively active kinase, specifically and sequentially phosphorylates serine/arginine (SR)-type shuttling mRNA binding proteins in their RS dipeptide repeats. |
Sequence Annotation | DOMAIN 158 706 Protein kinase.
NP_BIND 164 172 ATP (By similarity).
ACT_SITE 294 294 Proton acceptor (By similarity).
BINDING 187 187 ATP (By similarity).
MOD_RES 383 383 Phosphothreonine.
MOD_RES 386 386 Phosphothreonine.
MOD_RES 388 388 Phosphoserine.
MOD_RES 393 393 Phosphoserine.
MOD_RES 410 410 Phosphoserine.
MOD_RES 427 427 Phosphoserine.
MOD_RES 432 432 Phosphoserine.
MOD_RES 445 445 Phosphoserine.
MOD_RES 449 449 Phosphoserine.
MOD_RES 453 453 Phosphoserine. |
Keyword | 3D-structure; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 742 AA |
Protein Sequence | MGSSINYPGF VTKSAHLADT STDASISCEE ATSSQEAKKN FFQRDYNMMK KAPAPTKSKL 60
SLALQTSKSS SSANGTVQED TSSKTEDFST KSIKKKPDSG VESHVSIQSD SGPQSDSDLD 120
SDSSISSCDE RNEESLKDYR PGGYHPAFKG EPYKDARYIL VRKLGWGHFS TVWLAKDMVN 180
NTHVAMKIVR GDKVYTEAAE DEIKLLQRVN DADNTKEDSM GANHILKLLD HFNHKGPNGV 240
HVVMVFEVLG ENLLALIKKY EHRGIPLIYV KQISKQLLLG LDYMHRRCGI IHTDIKPENV 300
LMEIGDVEGI VQMVEALDKQ KREAKRLQRH VSRSSDITAN DSSDEKWAEC QTSMPCGSSS 360
NSKSRSIEKD LSKRCFRRPR RHTIITGSQP LPSPISSSNF FEMRAHFCGS SHNSFSSVSG 420
NRNIPSSINN NSINNGIGIK NSNNSFLNSV PHSVTRMFIN EDSNDNNNND NSKNKNNNNN 480
NSNNNNNEDI MNTPLHEEQL ADSLSTFDIS NISQSSDTNG PYISNTMDSN SNVSTDINSP 540
ENLIQIKIAD LGNACWYDEH YTNSIQTREY RSPEVLLGAP WGCGADIWST ACLIFELITG 600
DFLFEPDEGH SYTKDDDHIA QIIELLGELP SYLLRNGKYT RTFFNSRGLL RNISKLKFWP 660
LEDVLTEKYK FSKDEAKEIS DFLSPMLQLD PRKRADAGGL VNHPWLKDTL GMEEIRVPDR 720
ELYGSGSDIP GWFEEVRDHK RH 742 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IDA:SGD. GO:0030003; P:cellular cation homeostasis; IMP:SGD. GO:0006376; P:mRNA splice site selection; IGI:SGD. GO:0042307; P:positive regulation of protein import into nucleus; IMP:SGD. GO:0008361; P:regulation of cell size; IMP:SGD. GO:0042493; P:response to drug; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |