CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024600
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Septin-8 
Protein Synonyms/Alias
  
Gene Name
 Sept8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
173SLDLVTMKKLDSKVNacetylation[1]
174LDLVTMKKLDSKVNIacetylation[1]
193AKADTISKSELHKFKacetylation[1]
198ISKSELHKFKIKIMGacetylation[1]
251EEVKVGNKLVRARQYacetylation[1]
331ETYEAKRKEFLSELQubiquitination[2]
360KETELELKEKERELHacetylation[1]
369KERELHEKFEHLKRIacetylation[1]
374HEKFEHLKRIHQEEKacetylation[1]
381KRIHQEEKRKVEEKRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). 
Sequence Annotation
 NP_BIND 51 58 GTP (By similarity).
 NP_BIND 187 195 GTP (By similarity).
 BINDING 106 106 GTP; via amide nitrogen (By similarity).
 BINDING 241 241 GTP; via amide nitrogen and carbonyl
 BINDING 256 256 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 141 141 Phosphoserine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MAATDLERIS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL 60
MNTFFNTTFE TEEASHHEEC VRLRPQTYDL QESNVHLKLT IVDAVGFGDQ INKDDSYRPI 120
VDYIDTQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN 180
IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV 240
GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY 300
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK 360
EKERELHEKF EHLKRIHQEE KRKVEEKRRE LEEETNAFNC RKAAMEALQS QALHATSQQP 420
LRKDKDKKKV GGWSSIYSVT IP 442 
Gene Ontology
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:InterPro. 
Interpro
 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 
Pfam
 PF00735; Septin 
SMART
  
PROSITE
  
PRINTS