CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017955
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and SCAN domain-containing protein 18 
Protein Synonyms/Alias
 Zinc finger protein 447 
Gene Name
 ZSCAN18 
Gene Synonyms/Alias
 ZNF447 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
174AQYPESCKKAASLVEubiquitination[1]
273ANTEQKLKSFPEDPQubiquitination[1]
296DPAEENLKSYRKLLLubiquitination[1]
300ENLKSYRKLLLWGYQubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 49 131 SCAN box.
 ZN_FING 413 435 C2H2-type 1.
 ZN_FING 441 463 C2H2-type 2.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 510 AA 
Protein Sequence
MRRVGGRADE DATAAGSLWV LAPPEPTGHL VIPGTSPLEP PCPWLDSHIF QCRFGKMLPL 60
EKAFASPRSS PAPPDLPTPG SAAGVQQEEP ETIPERTPAD LEFSRLRFRE FVYQEAAGPH 120
QTLARLHELC RQWLMPEARS KEQMLELLVL EQFLGILPDK VRPWVVAQYP ESCKKAASLV 180
EGLADVLEEP GMLLGSPAGS SSILSDGVYE RHMDPLLLPG ELASPSQALG AGEIPAPSET 240
PWLSPDPLFL EQRRVREAKT EEDGPANTEQ KLKSFPEDPQ HLGEWGHLDP AEENLKSYRK 300
LLLWGYQLSQ PDAASRLDTE ELRLVERDPQ GSSLPEGGRR QESAGCACEE AAPAGVLPEL 360
PTEAPPGDAL ADPPSGTTEE EEEQPGKAPD PQDPQDAESD SATGSQRQSV IQQPAPDRGT 420
AKLGTKRPHP EDGDGQSLEG VSSSGDSAGL EAGQGPGADE PGLSRGKPYA CGECGEAFAW 480
LSHLMEHHSS HGGRKRYACQ GCWKTFHFSL ALAEHQKTHE KEKSYALGGA RGPQPSTREA 540
QAGARAGGPP ESVEGEAPPA PPEAQR 566 
Gene Ontology
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IBA:RefGenome.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016032; P:viral reproduction; IEA:InterPro. 
Interpro
 IPR008916; Retrov_capsid_C.
 IPR003309; Tscrpt_reg_SCAN.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF02023; SCAN
 PF00096; zf-C2H2 
SMART
 SM00431; SCAN
 SM00355; ZnF_C2H2 
PROSITE
 PS50804; SCAN_BOX
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS