UniProt Accession

 HHEX_HUMAN; Q03014; B1AQ17; Q96CE9 

Genbank Protein ID

 X67235; L16499; AK314891; AL590080; CH471066; CH471066; BC014336; BC015110; BC050638; Z21533 

Genbank Nucleotide ID

 CAA47661.1; AAA02988.1; BAG37405.1; CAH74086.1; EAW50087.1; EAW50088.1; AAH14336.1; AAH15110.1; AAH50638.1; CAA79730.1 

Protein Name

 Hematopoietically-expressed homeobox protein HHEX 

Protein Synonyms/Alias

 Homeobox protein HEX; Homeobox protein PRH 

Gene Name

 HHEX 

Gene Synonyms/Alias

 HEX; PRH; PRHX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	LRHDPLGKPLLWSPF	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). 

Sequence Annotation

 DNA_BIND 137 196 Homeobox.  

Keyword

 3D-structure; Complete proteome; Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 270 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0032993; C:protein-DNA complex; IDA:BHF-UCL.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0008301; F:DNA binding, bending; IDA:BHF-UCL.
 GO:0008190; F:eukaryotic initiation factor 4E binding; IDA:BHF-UCL.
 GO:0070491; F:repressing transcription factor binding; IDA:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0017025; F:TBP-class protein binding; TAS:BHF-UCL.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
 GO:0030183; P:B cell differentiation; ISS:BHF-UCL.
 GO:0007049; P:cell cycle; IDA:BHF-UCL.
 GO:0008283; P:cell proliferation; IDA:BHF-UCL.
 GO:0061009; P:common bile duct development; IEA:Compara.
 GO:0071103; P:DNA conformation change; IDA:BHF-UCL.
 GO:0035050; P:embryonic heart tube development; IEA:Compara.
 GO:0048568; P:embryonic organ development; IEA:Compara.
 GO:0007492; P:endoderm development; IEA:Compara.
 GO:0048853; P:forebrain morphogenesis; IEA:Compara.
 GO:0061010; P:gall bladder development; IEA:Compara.
 GO:0061011; P:hepatic duct development; IEA:Compara.
 GO:0061017; P:hepatoblast differentiation; IEA:Compara.
 GO:0070365; P:hepatocyte differentiation; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0022027; P:interkinetic nuclear migration; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0002573; P:myeloid leukocyte differentiation; IEA:Compara.
 GO:0016525; P:negative regulation of angiogenesis; ISS:BHF-UCL.
 GO:0010944; P:negative regulation of transcription by competitive promoter binding; TAS:BHF-UCL.
 GO:0010621; P:negative regulation of transcription by transcription factor localization; IC:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:BHF-UCL.
 GO:0031016; P:pancreas development; IEA:Compara.
 GO:0016973; P:poly(A)+ mRNA export from nucleus; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0030177; P:positive regulation of Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:0060431; P:primary lung bud formation; IEA:Compara.
 GO:0090009; P:primitive streak formation; IEA:Compara.
 GO:0034504; P:protein localization to nucleus; IDA:BHF-UCL.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0030878; P:thyroid gland development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS

 PR00024; HOMEOBOX.