CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031534
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATPase family AAA domain-containing protein 1 
Protein Synonyms/Alias
 cDNA FLJ54240, highly similar to ATPase family AAA domain-containing protein 1 
Gene Name
 ATAD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54DTVILPIKKKHLFENubiquitination[1, 2]
56VILPIKKKHLFENSRubiquitination[3]
69SRLLQPPKGVLLYGPubiquitination[3]
81YGPPGCGKTLIAKATubiquitination[3]
86CGKTLIAKATAKEAGubiquitination[3]
107QPSTLTDKWYGESQKubiquitination[2, 3, 4]
182KQREAILKLILKNENubiquitination[1, 5]
186AILKLILKNENVDRHubiquitination[2, 3, 5]
212GFSGSDLKEMCRDAAubiquitination[3, 6]
259IEKMKKSKDAAFQNVubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 273 AA 
Protein Sequence
MKQIGVKNVK LSEYEMSIAA HLVDPLNMHV TWSDIAGLDD VITDLKDTVI LPIKKKHLFE 60
NSRLLQPPKG VLLYGPPGCG KTLIAKATAK EAGCRFINLQ PSTLTDKWYG ESQKLAAAVF 120
SLAIKLQPSI IFIDEIDSFL RNRSSSDHEA TAMMKAQFMS LWDGLDTDHS CQALKQREAI 180
LKLILKNENV DRHVDLLEVA QETDGFSGSD LKEMCRDAAL LCVREYVNST SEESHDEDEI 240
RPVQQQDLHR AIEKMKKSKD AAFQNVLTHV CLD 273 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS