CPLM-023950

Genbank Nucleotide ID

UbiA prenyltransferase domain-containing protein 1

Protein Synonyms/Alias

Transitional epithelial response protein 1

Homo sapiens (Human)

Position	Peptide	Type	References
10	ASQVLGEKINILSGE	ubiquitination	[1, 2, 3, 4]
114	FSKGIDHKKSDDRTL	ubiquitination	[5]
115	SKGIDHKKSDDRTLV	ubiquitination	[5]
307	FRSQAFNKLPQRTAK	ubiquitination	[2, 5]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
[5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2- methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.

MOD_RES 2 2 N-acetylalanine.

Acetylation; Alternative splicing; Complete proteome; Corneal dystrophy; Cytoplasm; Disease mutation; Endoplasmic reticulum; Golgi apparatus; Membrane; Menaquinone biosynthesis; Mitochondrion; Nucleus; Prenyltransferase; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Ubiquinone biosynthesis.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0030173; C:integral to Golgi membrane; IDA:UniProtKB.
GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016209; F:antioxidant activity; IMP:UniProtKB.
GO:0004659; F:prenyltransferase activity; IDA:UniProtKB.
GO:0009234; P:menaquinone biosynthetic process; IMP:UniProtKB.
GO:0006744; P:ubiquinone biosynthetic process; IMP:UniProtKB.
GO:0042371; P:vitamin K biosynthetic process; IDA:UniProtKB.

IPR000537; UbiA_prenyltransferase.
IPR026046; UBIAD1.