UniProt Accession

 HACD1_HUMAN; B0YJ81; B0YJ80; Q6JIC5; Q96FW7; Q9HB93; Q9UHX2 

Genbank Protein ID

 AF266852; AF266848; AF266849; AF266850; AF266851; AF114494; AY455942; BC010353; EF445016; EF445016; EF445016; CR608689 

Genbank Nucleotide ID

 AAG10713.1; AAG10713.1; AAG10713.1; AAG10713.1; AAG10713.1; AAF21976.1; AAR22554.1; AAH10353.1; ACA06060.1; ACA06061.1; ACA06059.1 

Protein Name

 Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1 

Protein Synonyms/Alias

 3-hydroxyacyl-CoA dehydratase 1; HACD1; Cementum attachment protein; Protein-tyrosine phosphatase-like member A 

Gene Name

 PTPLA 

Gene Synonyms/Alias

 HACD1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	GTHRGLYKSIQKTLK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. 

Sequence Annotation

 ACT_SITE 210 210 By similarity.
 ACT_SITE 217 217 By similarity.
 MOD_RES 22 22 Phosphoserine.
 CARBOHYD 243 243 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Developmental protein; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Lyase; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
 GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0007165; P:signal transduction; NAS:ProtInc. 

Interpro

 IPR007482; Tyr_Pase-like_PTPLA. 

Pfam

 PF04387; PTPLA 

SMART

  

PROSITE

  

PRINTS