UniProt Accession

 MAGT1_HUMAN; Q9H0U3; B2RAR4; D3DTE3; Q53G00; Q8NBN6 

Genbank Protein ID

 DQ000004; AY358691; AK075394; AL136636; AK223131; AK314309; AL138743; AL356235; AL356235; AL138743; CH471104; CH471104; BC041014; BC060842 

Genbank Nucleotide ID

 AAY18811.1; AAQ89054.1; BAC11592.1; CAB66571.1; BAD96851.1; BAG36961.1; CAI39753.1; CAI39753.1; CAH70524.1; CAH70524.1; EAW98609.1; EAW98610.1; AAH41014.1; AAH60842.1 

Protein Name

 Magnesium transporter protein 1 

Protein Synonyms/Alias

 MagT1; Implantation-associated protein; IAP 

Gene Name

 MAGT1 

Gene Synonyms/Alias

 IAG2; PSEC0084; UNQ628/PRO1244 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	KEMVLSEKVSQLMEW	ubiquitination	[1]
50	QLMEWTNKRPVIRMN	ubiquitination	[2, 3, 4]
66	DKFRRLVKAPPRNYS	ubiquitination	[1]
91	HRQCVVCKQADEEFQ	ubiquitination	[1, 5]
324	MLSIFRSKYHGYPYS	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells. 

Sequence Annotation

 DOMAIN 47 175 Thioredoxin.
 CARBOHYD 71 71 N-linked (GlcNAc...) (Potential).
 DISULFID 87 90 Redox-active (By similarity).  

Keyword

 Cell membrane; Complete proteome; Disease mutation; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Magnesium; Membrane; Mental retardation; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0008250; C:oligosaccharyltransferase complex; IDA:HGNC.
 GO:0015095; F:magnesium ion transmembrane transporter activity; IMP:UniProtKB.
 GO:0050890; P:cognition; IMP:UniProtKB.
 GO:0006487; P:protein N-linked glycosylation; NAS:UniProtKB. 

Interpro

 IPR006844; Mg_transporter-1.
 IPR021149; OligosaccharylTrfase_OST3/OST6.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF04756; OST3_OST6 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS