UniProt Accession

 ABI2_HUMAN; Q9NYB9; B4DSN1; Q13147; Q13249; Q13801; Q9BV70 

Genbank Protein ID

 U23435; U31089; AF260261; X95632; BT009920; AK299824; BC001439 

Genbank Nucleotide ID

 AAA92289.1; AAA75446.1; AAF70308.1; CAA64885.1; AAP88922.1; BAG61693.1; AAH01439.1 

Protein Name

 Abl interactor 2 

Protein Synonyms/Alias

 Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1 

Gene Name

 ABI2 

Gene Synonyms/Alias

 ARGBPIA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
43	NYIQSADKQRALEET	ubiquitination	[1]
139	RPVRYIRKPIDYTIL	ubiquitination	[1]
167	KVSTQNMKMGGLPRT	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. 

Sequence Annotation

 DOMAIN 45 107 t-SNARE coiled-coil homology.
 DOMAIN 451 510 SH3.
 MOD_RES 227 227 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.
 MOD_RES 462 462 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 513 AA 

Protein Sequence

Gene Ontology

 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0030175; C:filopodium; IDA:UniProtKB.
 GO:0030027; C:lamellipodium; IDA:UniProtKB.
 GO:0008093; F:cytoskeletal adaptor activity; TAS:UniProtKB.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0019900; F:kinase binding; NAS:UniProtKB.
 GO:0017124; F:SH3 domain binding; TAS:UniProtKB.
 GO:0008154; P:actin polymerization or depolymerization; NAS:UniProtKB.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0016477; P:cell migration; TAS:UniProtKB.
 GO:0016358; P:dendrite development; IEA:Compara.
 GO:0007611; P:learning or memory; IEA:Compara.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI. 

Interpro

 IPR012849; Abl-interactor_HHR_dom.
 IPR001452; SH3_domain.
 IPR000727; T_SNARE_dom. 

Pfam

 PF07815; Abi_HHR
 PF00018; SH3_1 

SMART

 SM00326; SH3 

PROSITE

 PS50002; SH3
 PS50192; T_SNARE 

PRINTS

 PR00452; SH3DOMAIN.