UniProt Accession

 ALDOB_HUMAN; P05062; Q13741; Q13742; Q5T7D6 

Genbank Protein ID

 X02747; D00183; M15656; M15657; AL353621; CH471105; X00270; X01098 

Genbank Nucleotide ID

 CAA26526.1; BAA00125.1; AAA51691.1; AAA51691.1; CAI14614.1; EAW58951.1; CAA25072.1; CAA25572.1 

Protein Name

 Fructose-bisphosphate aldolase B 

Protein Synonyms/Alias

 Liver-type aldolase 

Gene Name

 ALDOB 

Gene Synonyms/Alias

 ALDB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
147	KDGVDFGKWRAVLRI	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 ACT_SITE 188 188 Proton acceptor (By similarity).
 ACT_SITE 230 230 Schiff-base intermediate with
 BINDING 56 56 Substrate.
 BINDING 147 147 Substrate.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 36 36 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; Glycolysis; Lyase; Phosphoprotein; Polymorphism; Reference proteome; Schiff base. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0034451; C:centriolar satellite; IDA:BHF-UCL.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0051117; F:ATPase binding; IDA:BHF-UCL.
 GO:0008092; F:cytoskeletal protein binding; IDA:BHF-UCL.
 GO:0070061; F:fructose binding; IMP:BHF-UCL.
 GO:0004332; F:fructose-bisphosphate aldolase activity; IDA:BHF-UCL.
 GO:0030388; P:fructose 1,6-bisphosphate metabolic process; IDA:BHF-UCL.
 GO:0006001; P:fructose catabolic process; TAS:Reactome.
 GO:0006094; P:gluconeogenesis; TAS:Reactome.
 GO:0006096; P:glycolysis; IDA:BHF-UCL.
 GO:0006116; P:NADH oxidation; IDA:BHF-UCL.
 GO:0032781; P:positive regulation of ATPase activity; IGI:BHF-UCL.
 GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IGI:BHF-UCL. 

Interpro

 IPR000741; Aldolase_I.
 IPR013785; Aldolase_TIM. 

Pfam

 PF00274; Glycolytic 

SMART

  

PROSITE

 PS00158; ALDOLASE_CLASS_I 

PRINTS