| Tag | Content |
|---|
| CPLM ID | CPLM-024295 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Anaphase-promoting complex subunit 5 |
Protein Synonyms/Alias | APC5; Cyclosome subunit 5 |
Gene Name | Anapc5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 369 | FAGKTANKLMDALKD | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). |
Sequence Annotation | REPEAT 286 319 TPR 1.
REPEAT 494 527 TPR 2.
REPEAT 553 586 TPR 3.
REPEAT 650 683 TPR 4.
MOD_RES 180 180 Phosphoserine (By similarity). |
Keyword | Cell cycle; Cell division; Complete proteome; Mitosis; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 727 AA |
Protein Sequence | MMTNGVVHAN LFGIKDWVTP YKIAVLVLLN EMGRTGEGAV SLVERRKLNQ LLLPLLQGPD 60
ITLSKLYKLI EESCPQLANS VQIRIKLMAE GELKDLEQFF DDLSDSFSGT EPEVHKTSVV 120
GLFLRHMILA YSKLSFSQVF KLYTALQQYF QNGEKKTVED ADMDREDGER QMEKEELDVS 180
VREEEVSCSG PLSQKQAEFF LSQQAALLKN DETKALTPAS LQKELNNLLK FNPDFAEAHY 240
LSYLNNLRVQ DVFSSTHSLL HYFDRLILTG AEGKSNGEEG YGRSLRYAAL NLAALHCRFG 300
HYQQAELALQ EAIRIAQESN DHVCLQHCLS WLYVLGQKRA DSYVLLEHSV KKAVHFGLPR 360
AFAGKTANKL MDALKDSDLL HWKHSLSELI DISIAQKTAI WRLYGRSTMA LQQAQMLLSM 420
NSLESLSAGV QQNNTESFAV ALCHLAELHA EQGCFAAAGE VLKHLKERFP PNSQHAQLWM 480
LCDQKIQFDR AMNDGKFHLA DSLVTGITAL NGIEGVYRKA VVLQAQNQMT EAHKLLQKLL 540
TYCQKLKNTE MVISVLLSVA ELYWRSSSPT IAMPVLLEAL ALSKEYRLQY LASETVLNLA 600
YAQLILGIPE QALTLLHMAI EPILADGAIL DKGRAMFLVS KCQVASAASY DPVKKAEALE 660
AAIQNLTEAK NYFAKVDCRE RIRDVSYFQA RLYHALGKTQ ERNHCAMVFR QLHQELPSHG 720
VPLINHL 727 |
Gene Ontology | GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |