CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027669
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Malate synthase 
Protein Synonyms/Alias
  
Gene Name
 aceB 
Gene Synonyms/Alias
 STM4183 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
43LVTRFTPKRNKLLAAacetylation[1]
46RFTPKRNKLLAARIQacetylation[1]
Reference
 [1] Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.
 Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao S, Zhao GP.
 Science. 2010 Feb 19;327(5968):1004-7. [PMID: 20167787] 
Functional Description
  
Sequence Annotation
 ACT_SITE 166 166 Proton acceptor (By similarity).
 ACT_SITE 447 447 Proton donor (By similarity).  
Keyword
 Acyltransferase; Complete proteome; Glyoxylate bypass; Reference proteome; Transferase; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MNPQATTTDE LTFTRPQGEL EKQVLTAEAV EFLTELVTRF TPKRNKLLAA RIQQQQDIDN 60
GKLPDFISET TSIRESNWQI RGIPADLQDR RVEITGPVER KMVINALNAN VKVFMADFED 120
SLAPDWNKVI DGQINLRDAV NGTISYTNEA GKIYQLKPDP AVLICRVRGL HLPEKHVTWR 180
GEAIPGSLFD FALYFFHNYK ALLAKGSGPY FYLPKTQAWQ EAAWWSEVFS YAEDRFNLPR 240
GTIKATLLIE TLPAVFQMDE ILHALRDHIV GLNCGRWDYI FSYIKTLKNH PDRVLPDRQV 300
VTMDKPFLSA YSRLLIKTCH KRGAFAMGGM AAFIPSKDVE RNNQVLAKVK ADKALEANNG 360
HDGTWIAHPG LADTAMAVFN EVLGEHKNQL FITRDEDAPI TAEQLLEPCE GERTEAGMRA 420
NIRVAVQYIE AWISGNGCVP IYGLMEDAAT AEISRTSIWQ WIHHEKTLSN GKPVTKTLFR 480
EMLAEEMRVI QDELGEHRYS SGRFDDAARL MEQITTSDDL IDFLTLPGYR LLA 533 
Gene Ontology
 GO:0004474; F:malate synthase activity; IEA:EC.
 GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-UniPathway.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR011076; Malate_synth-like.
 IPR006252; Malate_synthA.
 IPR001465; Malate_synthase.
 IPR019830; Malate_synthase_CS. 
Pfam
 PF01274; Malate_synthase 
SMART
  
PROSITE
 PS00510; MALATE_SYNTHASE 
PRINTS