UniProt Accession

 FANCG_HUMAN; O15287 

Genbank Protein ID

 U70310; AJ007669; AY795970; AC004472; AL353795; BC000032; BC011623 

Genbank Nucleotide ID

 AAB80802.1; CAA07602.1; AAV40841.1; AAC07981.1; CAH70994.1; AAH00032.1; AAH11623.1 

Protein Name

 Fanconi anemia group G protein 

Protein Synonyms/Alias

 Protein FACG; DNA repair protein XRCC9 

Gene Name

 FANCG 

Gene Synonyms/Alias

 XRCC9 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
28	DRLVRQAKVAQNSGL	ubiquitination	[1]
430	RTSSLLPKMSRLWED	ubiquitination	[1]
491	FRATPEEKEQGAAFN	ubiquitination	[1, 2]
504	FNCEQGCKSDAALQQ	ubiquitination	[1, 2]
559	FHLLQTLKRLDRRDE	ubiquitination	[1, 2, 3, 4, 5, 6]
618	EFRTSLPKSCDL***	ubiquitination	[1, 7]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. 

Sequence Annotation

 REPEAT 246 279 TPR 1.
 REPEAT 344 377 TPR 2.
 REPEAT 453 486 TPR 3.
 REPEAT 514 547 TPR 4.
 MOD_RES 7 7 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Disease mutation; DNA damage; DNA repair; Fanconi anemia; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 622 AA 

Protein Sequence

Gene Ontology

 GO:0043240; C:Fanconi anaemia nuclear complex; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0003684; F:damaged DNA binding; TAS:ProtInc.
 GO:0000075; P:cell cycle checkpoint; TAS:ProtInc.
 GO:0006281; P:DNA repair; TAS:Reactome.
 GO:0007005; P:mitochondrion organization; IMP:UniProtKB.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0009314; P:response to radiation; IEA:Compara.
 GO:0007286; P:spermatid development; IEA:Compara. 

Interpro

 IPR001440; TPR-1.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS