CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014816
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HEAT repeat-containing protein 6 
Protein Synonyms/Alias
 Amplified in breast cancer protein 1 
Gene Name
 HEATR6 
Gene Synonyms/Alias
 ABC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
267GALLAVLKKFMFHGLubiquitination[1]
411AEGGMQSKMRSYQAKubiquitination[1, 2]
556NAPYDRLKLSLLTKVubiquitination[3, 4]
748TGLIQQYKPDSTAAPubiquitination[1]
1029AALSVPGKREQYGSVubiquitination[1]
1137QMVRMALKHMGSIQAubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Amplification-dependent oncogene. 
Sequence Annotation
 REPEAT 159 198 HEAT 1.
 REPEAT 452 490 HEAT 2.
 REPEAT 515 552 HEAT 3.
 REPEAT 558 595 HEAT 4.
 MOD_RES 643 643 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1181 AA 
Protein Sequence
MAAVQVVGSW PSVQPREAPR EAIPERGNGF RLLSARLCAL RPDDSSSART EIHLLFDQLI 60
SENYSEGSGV APEDVSALLV QACRLVPLNQ NHLVSKVSQL IHHLLNRLQV IVDEQHLDFL 120
LAYTISAIHQ CSSWTHREIL QALAALVYCN GSKCQKYLPE LLGNTGLLMK LSDLAQSDPE 180
VRRAAVHCMA NLCLSVPGQP YLEEPYQNVC FQAFLTILQS PKSSDMDDIT FCMLLQNALK 240
GIQSLLNGGR MKLTQTDELG ALLAVLKKFM FHGLPGLNIE MPTVLYPTPL PQYDGRTPIK 300
PQQSESSASR PTLNKKKKSK VKPKKIQQGE EEEKESSGEI EAAPVTGTGR VNLHEGNTWC 360
PSSLGVQSLP LDGSGAAEKD GVSSSFSSSS WKRVSSSESD FSDAEGGMQS KMRSYQAKVR 420
QGALVCFLST IKSIEKKVLY GYWSAFIPDT PELGSPQSVS LMTLTLKDPS PKTRACALQV 480
LSAILEGSKQ FLSVAEDTSD HRRAFTPFSV MIACSIRELH RCLLLALVAE SSSQTVTQII 540
KCLANLVSNA PYDRLKLSLL TKVWNQIKPY IRHKDVNVRV SSLTLLGAIV STHAPLPEVQ 600
LLLQQPCSSG LGNSNSATPH LSPPDWWKKA PAGPSLEETS VSSPKGSSEP CWLIRLCISI 660
VVLPKEDSCS GSDAGSAAGS TYEPSPMRLE ALQVLTLLAR GYFSMTQAYL MELGEVICKC 720
MGEADPSIQL HGAKLLEELG TGLIQQYKPD STAAPDQRAP VFLVVMFWTM MLNGPLPRAL 780
QNSEHPTLQA SACDALSSIL PEAFSNLPND RQMLCITVLL GLNDSKNRLV KAATSRALGV 840
YVLFPCLRQD VIFVADAANA ILMSLEDKSL NVRAKAAWSL GNLTDTLIVN METPDPSFQE 900
EFSGLLLLKM LRSAIEASKD KDKVKSNAVR ALGNLLHFLQ PSHIEKPTFA EIIEESIQAL 960
ISTVLTEAAM KVRWNACYAM GNVFKNPALP LGTAPWTSQA YNALTSVVTS CKNFKVRIRS 1020
AAALSVPGKR EQYGSVDQYA RIWNALVTAL QKSEDTIDFL EFKYCVSLRT QICQALIHLL 1080
SLASASDLPC MKETLELSGN MVQSYILQFL KSGAEGDDTG APHSPQERDQ MVRMALKHMG 1140
SIQAPTGDTA RRAIMGFLEE ILAVCFDSSG SQGALPGLTN Q 1181 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR025283; DUF4042. 
Pfam
 PF13251; DUF4042 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS