CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023216
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-box transcription factor TBX20 
Protein Synonyms/Alias
 T-box protein 20 
Gene Name
 TBX20 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
198FTGEQLLKQMVSFEKubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart (By similarity). 
Sequence Annotation
 DNA_BIND 109 288 T-box.  
Keyword
 Atrial septal defect; Cardiomyopathy; Complete proteome; Developmental protein; Disease mutation; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 447 AA 
Protein Sequence
MEFTASPKPQ LSSRANAFSI AALMSSGGSK EKEATENTIK PLEQFVEKSS CAQPLGELTS 60
LDAHGEFGGG SGSSPSSSSL CTEPLIPTTP IIPSEEMAKI ACSLETKELW DKFHELGTEM 120
IITKSGRRMF PTIRVSFSGV DPEAKYIVLM DIVPVDNKRY RYAYHRSSWL VAGKADPPLP 180
ARLYVHPDSP FTGEQLLKQM VSFEKVKLTN NELDQHGHII LNSMHKYQPR VHIIKKKDHT 240
ASLLNLKSEE FRTFIFPETV FTAVTAYQNQ LITKLKIDSN PFAKGFRDSS RLTDIERESV 300
ESLIQKHSYA RSPIRTYGGE EDVLGDESQT TPNRGSAFTT SDNLSLSSWV SSSSSFPGFQ 360
HPQSLTALGT STASIATPIP HPIQGSLPPY SRLGMPLTPS AIASSMQGSG PTFPSFHMPR 420
YHHYFQQGPY AAIQGLRHSS AVMTPFV 447 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:BHF-UCL.
 GO:0005634; C:nucleus; ISS:BHF-UCL.
 GO:0001102; F:RNA polymerase II activating transcription factor binding; ISS:BHF-UCL.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0001105; F:RNA polymerase II transcription coactivator activity; IDA:BHF-UCL.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0003180; P:aortic valve morphogenesis; IMP:BHF-UCL.
 GO:0060413; P:atrial septum morphogenesis; IMP:BHF-UCL.
 GO:0008015; P:blood circulation; IEA:Compara.
 GO:0003207; P:cardiac chamber formation; ISS:BHF-UCL.
 GO:0055008; P:cardiac muscle tissue morphogenesis; ISS:BHF-UCL.
 GO:0003215; P:cardiac right ventricle morphogenesis; ISS:BHF-UCL.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0009953; P:dorsal/ventral pattern formation; ISS:BHF-UCL.
 GO:0036306; P:embryonic heart tube elongation; IEA:Compara.
 GO:0003272; P:endocardial cushion formation; ISS:BHF-UCL.
 GO:0001706; P:endoderm formation; ISS:BHF-UCL.
 GO:0035922; P:foramen ovale closure; IMP:BHF-UCL.
 GO:0001947; P:heart looping; ISS:BHF-UCL.
 GO:0048370; P:lateral mesoderm formation; ISS:BHF-UCL.
 GO:0006936; P:muscle contraction; IEA:Compara.
 GO:0010991; P:negative regulation of SMAD protein complex assembly; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0003148; P:outflow tract septum morphogenesis; IMP:BHF-UCL.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0003344; P:pericardium morphogenesis; ISS:BHF-UCL.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISS:BHF-UCL.
 GO:0003193; P:pulmonary valve formation; ISS:BHF-UCL.
 GO:0060577; P:pulmonary vein morphogenesis; IMP:BHF-UCL.
 GO:0003175; P:tricuspid valve development; ISS:BHF-UCL.
 GO:0021524; P:visceral motor neuron differentiation; ISS:BHF-UCL. 
Interpro
 IPR008967; p53-like_TF_DNA-bd.
 IPR001699; TF_T-box.
 IPR018186; TF_T-box_CS. 
Pfam
 PF00907; T-box 
SMART
 SM00425; TBOX 
PROSITE
 PS01283; TBOX_1
 PS01264; TBOX_2
 PS50252; TBOX_3 
PRINTS
 PR00937; TBOX.