CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000016
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AH receptor-interacting protein 
Protein Synonyms/Alias
 AIP; Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; XAP-2; Immunophilin homolog ARA9 
Gene Name
 AIP 
Gene Synonyms/Alias
 XAP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15LREDGIQKRVIQEGRubiquitination[1]
33PDFQDGTKATFHYRTubiquitination[1]
58DDSRARGKPMELIIGubiquitination[1]
66PMELIIGKKFKLPVWacetylation[2]
67MELIIGKKFKLPVWEubiquitination[1]
69LIIGKKFKLPVWETIubiquitination[1]
103VLYPLVAKSLRNIAVubiquitination[1]
112LRNIAVGKDPLEGQRubiquitination[1]
177MTDEEKAKAVPLIHQubiquitination[1]
201HVKEAAAKYYDAIACubiquitination[1]
210YDAIACLKNLQMKEQubiquitination[1]
266NKYDDNVKAYFKRGKubiquitination[1, 3]
273KAYFKRGKAHAAVWNubiquitination[1, 3, 4]
290EAQADFAKVLELDPAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. 
Sequence Annotation
 DOMAIN 31 121 PPIase FKBP-type.
 REPEAT 179 212 TPR 1.
 REPEAT 265 298 TPR 2.  
Keyword
 3D-structure; Complete proteome; Cushing syndrome; Cytoplasm; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 330 AA 
Protein Sequence
MADIIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHYRT LHSDDEGTVL DDSRARGKPM 60
ELIIGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL VAKSLRNIAV GKDPLEGQRH 120
CCGVAQMREH SSLGHADLDA LQQNPQPLIF HMEMLKVESP GTYQQDPWAM TDEEKAKAVP 180
LIHQEGNRLY REGHVKEAAA KYYDAIACLK NLQMKEQPGS PEWIQLDQQI TPLLLNYCQC 240
KLVVEEYYEV LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP 300
VVSRELQALE ARIRQKDEED KARFRGIFSH 330 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0036004; F:GAF domain binding; IDA:UniProtKB.
 GO:0004871; F:signal transducer activity; TAS:ProtInc.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0008134; F:transcription factor binding; TAS:ProtInc.
 GO:0051082; F:unfolded protein binding; IDA:HGNC.
 GO:0051344; P:negative regulation of cyclic-nucleotide phosphodiesterase activity; IEA:Compara.
 GO:0022417; P:protein maturation by protein folding; IDA:HGNC.
 GO:0006626; P:protein targeting to mitochondrion; IDA:HGNC.
 GO:0010738; P:regulation of protein kinase A signaling cascade; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; IEA:Compara. 
Interpro
 IPR001179; PPIase_FKBP_dom.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00254; FKBP_C 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS