CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Eif2ak4 
Protein Synonyms/Alias
  
Gene Name
 Eif2ak4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1259NSLCRLYKFIEQKGDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1649 AA 
Protein Sequence
MAGGRGAAGR GPAEPQESYS QRQDHELQAL EAIYGSDFQD LRPDARGRVR EPPEINLVLY 60
PQGLAGEEVY VQVELRVKCP PTYPDVVPEI ELKNTKGLSN ESVNLLKSHL EELAKKQCGE 120
VMIFELAHHV QSFLSEHNKP PPKSFHEEML ERQAQEKQQR LLEARQKEEQ EQREILHEIQ 180
KRKEEIKEEK KRKEMAKQER LEITSLTNQD HASKRDPAGH RAAAFLHGGS PDFVGNGKAR 240
AHSSGRSRRE RQYSVCSGEA SPGSCDILYF CVGSADQLMV HKGKCVGSDE QLGKVVYNAL 300
ETATGSFVLL YEWVLQWQKK MGPCLTSQEK EKIDKCKKQI QGAETEFSSL VKLSHPNIVR 360
YFAMNSREEK DSIVVDILAE HISGISLAAH LSHSGPVPMH QLRKYTAQLL AGLDYLHRNS 420
VVHKVLSTAS VLVDAEGTVK ITDYSISKRL ADICKEDVFE QTRVRFSDSA LPYKTGKKGD 480
VWRLGLLLLS LSQGQECEEY PVTIPSDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFIN 540
PQPKMPLVEQ SPEDSGGQDY IETIIPSNQL PSAAFFTETQ RQFSRYFIEF EELQLLGKGA 600
FGAVIKVQNK LDGCCYAVKR IPINPASRQF RRIKGEVTLL SRLHHENIVR YYNAWIERHE 660
RPAVPGTPPP DYIPQAQNSS ATGGKASGDT EELGSVEAAA PPPILSSSVE WSTSAERSNS 720
ARFPVTGQDS SSDEEDEDER DGVFSQSFLP ASDSDSDIIF DNEDENSKSQ NQDEDCNEKD 780
SRHEIEPSVT TEAVHYLYIQ MEYCEKSTLR DTIDQGLFRD TSRLWRLFRE ILDGLAYIHE 840
KGMIHRDLKP VNIFLDSDDH VKIGDFGLAT DHLAFNAEGK QDDQAGDHVI KSDPSGHLTG 900
MVGTALYVSP EVQGSTKSAY NQKVDLFSLG IILFEMSYHP MVTASERIFV LNQLRDPTSP 960
KFPDDFEDGE HTKQKSVISW LLNHDPAKRP TAMELLKSEL LPPPQMEESE LHEVLHHTLA 1020
NTDGKAYRTM MSQLFCQHSS PAIDYTYDSD ILKGNFLIRT AKIQQLVCET IVRVFKRHGA 1080
VQLCTPLLLP RNRQIYEHNE AALFMDHSGM LVMLPFDLRV PFARYVARNN ILNLKRYCIE 1140
RVFRPRKLDR FHPKELLECA FDIVTSTANS SLPTAETIYT IYEVIQEFPA LQERNYSIYL 1200
NHTMLLKAIL LHCGIPEDKL SQVYVILYDA VTEKLTRREV EAKFCNLSLS SNSLCRLYKF 1260
IEQKGDLQDL TPTINSLIKQ KTGIAQLVKY SLKDLEEVVG LLKKLGVKLQ VSINLGLVYK 1320
VQQHNGIIFQ FLAFSKRRQR VVPEILAAGG RYDLLIPKFR GPQALGPVPT AVGVSIAIDK 1380
IFAAVLNMGE PVTVSSCDLL VVSAGQMSMS RAINLTQKLW TAGITAEIMY DWSQSQEELQ 1440
EYCRHHEITY VALVSDKEGS HVKVKSFEKE RQTEKRVLES DLVDHVMQKL RTKVGDERNF 1500
RDASDNLAVQ TLKGSFSNAS GLFEIHGTTV VPTVSVISPE KLSASTRRRH EIQVQTRLQT 1560
TLANLHQKSS EIEILAVDLP KETILQFLSL EWDADEQAFN TTVKQLLSRL PKQRYLKLVC 1620
DEIYNIKVEK KVSVLFLYSY RDDYYRILF 1649 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IEA:InterPro.
 GO:0006446; P:regulation of translational initiation; IEA:InterPro. 
Interpro
 IPR004154; Anticodon-bd.
 IPR026920; EIF2AK4.
 IPR024435; HisRS-related_dom.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR006575; RWD-domain.
 IPR008271; Ser/Thr_kinase_AS.
 IPR016255; Ser/Thr_kinase_GCN2.
 IPR016135; UBQ-conjugating_enzyme/RWD. 
Pfam
 PF12745; HGTP_anticodon2
 PF00069; Pkinase
 PF05773; RWD 
SMART
 SM00591; RWD 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50908; RWD 
PRINTS