CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031568
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calsyntenin-1 
Protein Synonyms/Alias
 cDNA FLJ61580, highly similar to Calsyntenin-1 
Gene Name
 CLSTN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
177KATVIEGKQYDSILRubiquitination[1, 2]
772SLLDRKFKLICSELNubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Membrane; Reference proteome; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 962 AA 
Protein Sequence
MLRRPAPALA PAARLLLAGL LCGGGVWAAR VNKHKPWLEP TYHGIVTEND NTVLLDPPLI 60
ALDKDAPLRF AESFEVTVTK EGEICGFKIH GQNVPFDAVV VDKSTGEGVI RSKEKLDCEL 120
QKDYSFTIQA YDCGKGPDGT NVKKSHKATV HIQVNDVNEY APVFKEKSYK ATVIEGKQYD 180
SILRVEAVDA DCSPQFSQIC SYEIITPDVP FTVDKDGYIK NTEKLNYGKE HQYKLTVTAY 240
DCGKKRATED VLVKISIKPT CTPGWQGWNN RIEYEPGTGA LAVFPNIHLE TCDEPVASVQ 300
ATVELETSHI GKGCDRDTYS EKSLHRLCGA AAGTAELLPS PSGSLNWTMG LPTDNGHDSD 360
QVFEFNGTQA VRIPDGVVSV SPKEPFTISV WMRHGPFGRK KETILCSSDK TDMNRHHYSL 420
YVHGCRLIFL FRQDPSEEKK YRPAEFHWKL NQVCDEEWHH YVLNVEFPSV TLYVDGTSHE 480
PFSVTEDYPL HPSKIETQLV VGACWQGGDL HMTQFFRGNL AGLTLRSGKL ADKKVIDCLY 540
TCKEGLDLQV LEDSGRGVQI QAHPSQLVLT LEGEDLGELD KAMQHISYLN SRQFPTPGIR 600
RLKITSTIKC FNEATCISVP PVDGYVMVLQ PEEPKISLSG VHHFARAASE FESSEGVFLF 660
PELRIISTIT REVEPEGDGA EDPTVQESLV SEEIVHDLDT CEVTVEGEEL NHEQESLEVD 720
MARLQQKGIE VSSSELGMTF TGVDTMASYE EVLHLLRYRN WHARSLLDRK FKLICSELNG 780
RYISNEFKVE VNVIHTANPM EHANHMAAQP QFVHPEHRSF VDLSGHNLAN PHPFAVVPST 840
ATVVIVVCVS FLVFMIILGV FRIRAAHRRT MRDQDTGKEN EMDWDDSALT ITVNPMETYE 900
DQHSSEEEEE EEEEEESEDG EEEDDITSAE SESSEEEEGE QGDPQNATRQ QQLEWDDSTL 960
SY 962 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR026914; Calsyntenin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp. 
Pfam
 PF00028; Cadherin 
SMART
 SM00112; CA 
PROSITE
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.