UniProt Accession

 FZD3_HUMAN; Q9NPG1 

Genbank Protein ID

 AB039723; AJ272427; AY005130 

Genbank Nucleotide ID

 BAA94968.1; CAB89114.1; AAF89088.1 

Protein Name

 Frizzled-3 

Protein Synonyms/Alias

 Fz-3; hFz3 

Gene Name

 FZD3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
170	FWCPRELKIDPDLGY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. 

Sequence Annotation

 DOMAIN 23 136 FZ.
 MOTIF 502 507 Lys-Thr-X-X-X-Trp motif, mediates
 CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
 CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).
 CARBOHYD 356 356 N-linked (GlcNAc...) (Potential).
 DISULFID 28 89 By similarity.
 DISULFID 36 82 By similarity.
 DISULFID 73 110 By similarity.
 DISULFID 99 133 By similarity.
 DISULFID 103 127 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Developmental protein; Direct protein sequencing; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 666 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IBA:RefGenome.
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0030424; C:axon; IBA:RefGenome.
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0030425; C:dendrite; IBA:RefGenome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0032589; C:neuron projection membrane; IBA:RefGenome.
 GO:0043025; C:neuronal cell body; IBA:RefGenome.
 GO:0048786; C:presynaptic active zone; IBA:RefGenome.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0042813; F:Wnt-activated receptor activity; IC:BHF-UCL.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:UniProtKB.
 GO:0033278; P:cell proliferation in midbrain; IBA:RefGenome.
 GO:0071679; P:commissural neuron axon guidance; IBA:RefGenome.
 GO:0001736; P:establishment of planar polarity; IBA:RefGenome.
 GO:0021754; P:facial nucleus development; IBA:RefGenome.
 GO:0007199; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; IBA:RefGenome.
 GO:0008406; P:gonad development; IBA:RefGenome.
 GO:0001942; P:hair follicle development; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IBA:RefGenome.
 GO:0001843; P:neural tube closure; IBA:RefGenome.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0036342; P:post-anal tail morphogenesis; IEA:Compara.
 GO:0001944; P:vasculature development; IBA:RefGenome. 

Interpro

 IPR000539; Frizzled.
 IPR015526; Frizzled/SFRP.
 IPR020067; Frizzled_dom.
 IPR026553; FZD3_chordata.
 IPR017981; GPCR_2-like. 

Pfam

 PF01534; Frizzled
 PF01392; Fz 

SMART

 SM00063; FRI 

PROSITE

 PS50038; FZ
 PS50261; G_PROTEIN_RECEP_F2_4 

PRINTS

 PR00489; FRIZZLED.