CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030351
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-directed RNA polymerase 
Protein Synonyms/Alias
  
Gene Name
 Polr3a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
711TPGQGLLKAKYELLNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome; Transcription; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1390 AA 
Protein Sequence
MVKEQFRETD VAKKISHICF GMKSPEEMRQ QAHIQVVSKN LYSQDNNHAP LLYGVLDHRM 60
GTSEKDRPCE TCGKNLADCL GHYGYIDLEL PCFHVGYFRA VIGILQMICK TCCHIMLSQE 120
EKQQFLDFLK RPGLTYLQKR GLKKKISDKC RKKSTCHYCG AFNGTVKKCG LLKIIHEKYK 180
TNKKVVDPIV SNFLQSFETA IEHNKEVEPL LGRAQENLNP LVVLNLFKRI PAEDVPLLLM 240
NPESGKPSDL ILTRLLVPPL CIRPSVVSDL KSGTNEDDLT MKLTEIIFLN DVIKKHRISG 300
AKTQMIMEDW DFLQLQCALY INSELSGIPL NMAPKKWTRG FVQRLKGKQG RFRGNLSGKR 360
VDFSGRTVIS PDPNLRIDEV AVPVHVAKIL TFPEKVNKAN INFLRKLVRN GPDVHPGANF 420
IQQRHMQMKR FLKYGNREKM AQELKFGDIV ERHLIDGDVV LFNRQPSLHK LSIMAHLARV 480
KPHRTFRFNE CVCTPYNADF DGDEMNLHLP QTEEAKAEAL VLMGTKANLV TPRNGEPLIA 540
AIQDFLTGAY LLTLKDTFFD RAKACQIIAS ILVGKDEKIK VRLPPPTILK PVTLWTGKQI 600
FSVILRPSDD NPVRANLRTK GKQYCGKGED LCVNDSYVTI QNSELMCGSM DKGTLGSGSK 660
NNIFYILLRD WGQNEAADAM SRLARLAPVY LSNRGFSIGI GDVTPGQGLL KAKYELLNAG 720
YKKCDEYIEA LNTGKLQQQP GCTAEETLEA LILKELSVIR DHAGSACLRE LDKSNSPLTM 780
ALCGSKGSFI NISQMIACVG QQAISGSRVP DGFENRSLPH FEKHSKLPAA KGFVANSFYS 840
GLTPTEFFFH TMAGREGLVD TAVKTAETGY MQRRLVKSLE DLCSQYDLTV RSSTGDIIQF 900
IYGGDGLDPA AMEGKDEPLE FKRVLDNIKA VYPCQTEPAL SKNDLTLTAE AIMKKNEFLC 960
CQDSFLQEIK TFIKGVSEKI KKTRDKYGIN DNGTTEPRVL YQLDRITPTQ IEKFLETCRD 1020
KYMRAQMEPG SAVGALCAQS IGEPGTQMTL KTFHFAGVAS MNITLGVPRI KEIINASKAI 1080
STPIITAQLD KDDDADYARL VKGRIEKTLL GEISEYIEEV FLPDDCFILV KLSLERIRLL 1140
RLEVNAETVR YSICTSKLRV KPGDVAVHGE AVVCVTPREN SKSSMYYVLQ FLKEDLPKVV 1200
VQGIPEVSRA VIHIDEQSGK EKFKLLVEGD NLRAVMATHG VKGTRTTSNN TYEVEKTLGI 1260
EAARTTIINE IQYTMVNHGM SIDRRHVMLL SDLMTYKGEV LGITRFGLAK MKESVLMLAS 1320
FEKTADHLFD AAYFGQKDSV CGVSECIIMG IPMNIGTGLF KLLHKANRDP KPPRRPLIFD 1380
THEFHIPLVT 1390 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0032549; F:ribonucleoside binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045087; P:innate immune response; IEA:Compara.
 GO:0032728; P:positive regulation of interferon-beta production; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR009010; Asp_de-COase-like_dom.
 IPR000722; RNA_pol_asu.
 IPR015700; RNA_pol_III_lsu.
 IPR006592; RNA_pol_N.
 IPR007080; RNA_pol_Rpb1_1.
 IPR007066; RNA_pol_Rpb1_3.
 IPR007083; RNA_pol_Rpb1_4.
 IPR007081; RNA_pol_Rpb1_5. 
Pfam
 PF04997; RNA_pol_Rpb1_1
 PF00623; RNA_pol_Rpb1_2
 PF04983; RNA_pol_Rpb1_3
 PF05000; RNA_pol_Rpb1_4
 PF04998; RNA_pol_Rpb1_5 
SMART
 SM00663; RPOLA_N 
PROSITE
  
PRINTS