CPLM-012140

Genbank Nucleotide ID

Calcium/calmodulin-dependent protein kinase type II subunit beta

Protein Synonyms/Alias

CaM kinase II subunit beta; CaMK-II subunit beta

Homo sapiens (Human)

Position	Peptide	Type	References
259	MLTINPAKRITAHEA	ubiquitination	[1]

[1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]

Functional Description

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

DOMAIN 14 272 Protein kinase.
NP_BIND 20 28 ATP (By similarity).
REGION 283 292 Autoinhibitory domain (By similarity).
REGION 291 301 Calmodulin-binding.
ACT_SITE 136 136 Proton acceptor (By similarity).
BINDING 43 43 ATP (By similarity).
MOD_RES 17 17 Phosphotyrosine (By similarity).
MOD_RES 287 287 Phosphothreonine; by autocatalysis.
MOD_RES 306 306 Phosphothreonine; by autocatalysis (By
MOD_RES 307 307 Phosphothreonine; by autocatalysis (By
MOD_RES 315 315 Phosphoserine (By similarity).
MOD_RES 367 367 Phosphoserine (By similarity).
MOD_RES 397 397 Phosphoserine (By similarity).

3D-structure; Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Kinase; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Sarcoplasmic reticulum; Serine/threonine-protein kinase; Transferase.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0051233; C:spindle midzone; IEA:Compara.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
GO:0060466; P:activation of meiosis involved in egg activation; IEA:Compara.
GO:0006816; P:calcium ion transport; IEA:Compara.
GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
GO:0002030; P:inhibitory G-protein coupled receptor phosphorylation; IEA:Compara.
GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Compara.
GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB.
GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.
GO:0090129; P:positive regulation of synapse maturation; ISS:UniProtKB.
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
GO:0051924; P:regulation of calcium ion transport; TAS:UniProtKB.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; TAS:UniProtKB.
GO:0014733; P:regulation of skeletal muscle adaptation; TAS:UniProtKB.
GO:0051823; P:regulation of synapse structural plasticity; TAS:UniProtKB.
GO:0032222; P:regulation of synaptic transmission, cholinergic; IEA:Compara.
GO:0046686; P:response to cadmium ion; IEA:Compara.

IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543; Ca/CaM-dep_prot_kinase-assoc.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.

PF08332; CaMKII_AD
PF00069; Pkinase

PS00107; PROTEIN_KINASE_ATP
PS50011; PROTEIN_KINASE_DOM
PS00108; PROTEIN_KINASE_ST