CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006754
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-N-acetylenolpyruvoylglucosamine reductase 
Protein Synonyms/Alias
 UDP-N-acetylmuramate dehydrogenase 
Gene Name
 murB 
Gene Synonyms/Alias
 STM4137; STMF1.1 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
317VRQKVGEKFNVWLEPacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Cell wall formation. 
Sequence Annotation
 DOMAIN 13 183 FAD-binding PCMH-type.
 ACT_SITE 159 159 By similarity.
 ACT_SITE 229 229 Proton donor (By similarity).
 ACT_SITE 325 325 By similarity.  
Keyword
 Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Peptidoglycan synthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 342 AA 
Protein Sequence
MTHSLKPWNT FGIDHCAKHI VCAENEQQLL SAWQQATREG LPVMILGEGS NVLFLENYAG 60
TVILNRLKGI EVNETADAWH LHVGAGENWH QLVRYALDNN MPGLENLALI PGCVGSSPIQ 120
NIGAYGVELQ RVCDYVDCVE LETGKRLRLS AAECRFGYRD SIFKNEYQDR VAIVAVGLRL 180
SKQWQPVLTY GDLTCLDPKT VTAQQVFDAV CHMRTTKLPD PKVNGNAGSF FKNPVVAADI 240
AMELLERFPN APHYPQADGS VKLAAGWLID QCQLKGVTIG GAAVHRQQAL VLINANDATS 300
KDVVALAHHV RQKVGEKFNV WLEPEVRFIG RSGEVNAVES IA 342 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IEA:HAMAP.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. 
Interpro
 IPR016169; CO_DH_flavot_FAD-bd_sub2.
 IPR016166; FAD-bd_2.
 IPR016167; FAD-bd_2_sub1.
 IPR003170; MurB.
 IPR011601; MurB_C.
 IPR006094; Oxid_FAD_bind_N. 
Pfam
 PF01565; FAD_binding_4
 PF02873; MurB_C 
SMART
  
PROSITE
 PS51387; FAD_PCMH 
PRINTS