CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043315
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase ARIH1 
Protein Synonyms/Alias
  
Gene Name
 ARIH1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
141LSHFNWDKEKLMERRacetylation[1, 2]
141LSHFNWDKEKLMERRubiquitination[2, 3, 4, 5]
143HFNWDKEKLMERRLIubiquitination[2, 4, 5, 6]
154RRLITDSKVKLKYQHubiquitination[2, 3, 5, 7]
156LITDSKVKLKYQHLIubiquitination[5]
158TDSKVKLKYQHLITNubiquitination[2, 5]
175VECNRLLKWCPAPDCubiquitination[2, 5]
187PDCHHVVKVQYPDAKubiquitination[2, 5, 6]
194KVQYPDAKPVRCKCGubiquitination[3, 5, 7]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 204 AA 
Protein Sequence
XSDEGYNYEF DEDEECSEED SGAEEEEDED DDEPDDDTLD LGEVELVEPG LGVGGERDGL 60
LCGETGGGGG SALGPGGGGG GGGGGGGGGP GHEQEEDYRY EVLTAEQILQ HMVECIREVN 120
EVIQNPATIT RILLSHFNWD KEKLMERRLI TDSKVKLKYQ HLITNSFVEC NRLLKWCPAP 180
DCHHVVKVQY PDAKPVRCKC GRQF 204 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR002867; Znf_C6HC. 
Pfam
 PF01485; IBR 
SMART
 SM00647; IBR 
PROSITE
  
PRINTS