UniProt Accession

 F5GXC8_HUMAN; F5GXC8 

Genbank Protein ID

 AL157369; AL158196 

Genbank Nucleotide ID

  

Protein Name

 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 SUCLA2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	VPKGYVAKSPDEAYA	ubiquitination	[1]
30	DEAYAIAKKLGSKDV	acetylation	[2]
31	EAYAIAKKLGSKDVV	ubiquitination	[3]
85	IGKKLFTKQTGEKGR	ubiquitination	[2, 3]
359	GTRVDDAKALIADSG	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Ligase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 405 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IEA:Compara.
 GO:0006105; P:succinate metabolic process; IEA:Compara.
 GO:0006104; P:succinyl-CoA metabolic process; IEA:Compara.
 GO:0006099; P:tricarboxylic acid cycle; IEA:Compara. 

Interpro

 IPR011761; ATP-grasp.
 IPR013650; ATP-grasp_succ-CoA_synth-type.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR005811; CoA_ligase.
 IPR017866; Succ-CoA_synthase_bsu_CS.
 IPR005809; Succ_CoA_synthase_bsu.
 IPR016102; Succinyl-CoA_synth-like. 

Pfam

 PF08442; ATP-grasp_2
 PF00549; Ligase_CoA 

SMART

  

PROSITE

 PS50975; ATP_GRASP
 PS01217; SUCCINYL_COA_LIG_3 

PRINTS