CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020384
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription regulator protein BACH2 
Protein Synonyms/Alias
 BTB and CNC homolog 2 
Gene Name
 BACH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
177TMDSETAKMACPRDQphosphoglycerylation[1]
202AAIPVAEKEEALLPEsumoylation[2]
276GLARGQIKSEPPSEEsumoylation[2]
421PGLEALCKQEGELDRsumoylation[2]
580NQVRPQIKCEQSYGTsumoylation[2]
Reference
 [1] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
 [2] Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2.
 Tashiro S, Muto A, Tanimoto K, Tsuchiya H, Suzuki H, Hoshino H, Yoshida M, Walter J, Igarashi K.
 Mol Cell Biol. 2004 Apr;24(8):3473-84. [PMID: 15060166] 
Functional Description
 Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). 
Sequence Annotation
 DOMAIN 37 103 BTB.
 DOMAIN 646 709 bZIP.
 REGION 651 667 Basic motif (By similarity).
 REGION 671 678 Leucine-zipper (By similarity).  
Keyword
 3D-structure; Activator; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 841 AA 
Protein Sequence
MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA HRAVLAACSE 60
YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL LSRENIREVI RCAEFLRMHN 120
LEDSCFSFLQ TQLLNSEDGL FVCRKDAACQ RPHEDCENSA GEEEDEEEET MDSETAKMAC 180
PRDQMLPEPI SFEAAAIPVA EKEEALLPEP DVPTDTKESS EKDALTQYPR YKKYQLACTK 240
NVYNASSHST SGFASTFRED NSSNSLKPGL ARGQIKSEPP SEENEEESIT LCLSGDEPDA 300
KDRAGDVEMD RKQPSPAPTP TAPAGAACLE RSRSVASPSC LRSLFSITKS VELSGLPSTS 360
QQHFARSPAC PFDKGITQGD LKTDYTPFTG NYGQPHVGQK EVSNFTMGSP LRGPGLEALC 420
KQEGELDRRS VIFSSSACDQ VSTSVHSYSG VSSLDKDLSE PVPKGLWVGA GQSLPSSQAY 480
SHGGLMADHL PGRMRPNTSC PVPIKVCPRS PPLETRTRTS SSCSSYSYAE DGSGGSPCSL 540
PLCEFSSSPC SQGARFLATE HQEPGLMGDG MYNQVRPQIK CEQSYGTNSS DESGSFSEAD 600
SESCPVQDRG QEVKLPFPVD QITDLPRNDF QMMIKMHKLT SEQLEFIHDV RRRSKNRIAA 660
QRCRKRKLDC IQNLECEIRK LVCEKEKLLS ERNQLKACMG ELLDNFSCLS QEVCRDIQSP 720
EQIQALHRYC PVLRPMDLPT ASSINPAPLG AEQNIAASQC AVGENVPCCL EPGAAPPGPP 780
WAPSNTSENC TSGRRLEGTD PGTFSERGPP LEPRSQTVTV DFCQEMTDKC TTDEQPRKDY 840
T 841 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR004827; bZIP.
 IPR008917; Euk_TF_DNA-bd. 
Pfam
 PF00651; BTB
 PF00170; bZIP_1 
SMART
 SM00338; BRLZ
 SM00225; BTB 
PROSITE
 PS50097; BTB
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS