UniProt Accession

 RIR2_YEAST; P09938; D6VWF6 

Genbank Protein ID

 M17221; M17789; Z49301; BK006943 

Genbank Nucleotide ID

 AAA34987.1; AAA34988.1; CAA89317.1; DAA08772.1 

Protein Name

 Ribonucleoside-diphosphate reductase small chain 1 

Protein Synonyms/Alias

 Ribonucleotide reductase R2 subunit 1; Ribonucleotide reductase small subunit 1 

Gene Name

 RNR2 

Gene Synonyms/Alias

 CRT6; YJL026W; J1271 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
8	MPKETPSKAAADALS	acetylation	[1]
20	ALSDLEIKDSKSNLN	acetylation	[1]
20	ALSDLEIKDSKSNLN	ubiquitination	[2]
28	DSKSNLNKELETLRE	acetylation	[1]
74	HKLKEMEKEEPLLNE	acetylation	[1]
92	RTVLFPIKYHEIWQA	ubiquitination	[2]
101	HEIWQAYKRAEASFW	ubiquitination	[2]
290	LFAHLKNKPDPAIVE	ubiquitination	[2]
371	GKTNFFEKRVSDYQK	ubiquitination	[2]
378	KRVSDYQKAGVMSKS	ubiquitination	[2]
384	QKAGVMSKSTKQEAG	ubiquitination	[2]
387	GVMSKSTKQEAGAFT	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center. 

Sequence Annotation

 ACT_SITE 183 183
 METAL 145 145 Iron 1.
 METAL 176 176 Iron 1.
 METAL 176 176 Iron 2.
 METAL 179 179 Iron 1.
 METAL 239 239 Iron 2.
 METAL 273 273 Iron 2.
 METAL 276 276 Iron 2.
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 41 41 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; DNA replication; Iron; Metal-binding; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 399 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005971; C:ribonucleoside-diphosphate reductase complex; IDA:SGD.
 GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IDA:SGD.
 GO:0046914; F:transition metal ion binding; IEA:InterPro.
 GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.
 GO:0009263; P:deoxyribonucleotide biosynthetic process; IDA:SGD.
 GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway. 

Interpro

 IPR009078; Ferritin-like_SF.
 IPR012348; RNR-rel.
 IPR000358; RNR_small. 

Pfam

 PF00268; Ribonuc_red_sm 

SMART

  

PROSITE

 PS00368; RIBORED_SMALL 

PRINTS