CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019952
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipoyl synthase, mitochondrial 
Protein Synonyms/Alias
 Lipoate synthase; LS; Lip-syn; mLIP1; Lipoic acid synthase 
Gene Name
 Lias 
Gene Synonyms/Alias
 Lip1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
317QPTKRHLKVEEYVTPacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable). 
Sequence Annotation
 METAL 105 105 Iron-sulfur 1 (4Fe-4S) (By similarity).
 METAL 110 110 Iron-sulfur 1 (4Fe-4S) (By similarity).
 METAL 116 116 Iron-sulfur 1 (4Fe-4S) (By similarity).
 METAL 136 136 Iron-sulfur 2 (4Fe-4S-S-AdoMet) (By
 METAL 140 140 Iron-sulfur 2 (4Fe-4S-S-AdoMet) (By
 METAL 143 143 Iron-sulfur 2 (4Fe-4S-S-AdoMet) (By  
Keyword
 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome; S-adenosyl-L-methionine; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MALRCWDTAR SLGSRIFGRY AFTVRALSSL PDKKKEFLHN GPDLQDFVSG DLADKSTWDE 60
YKGNLKRQKG ERLRLPPWLK TKIPMGKNYN KLKNTLRNLS LHTVCEEARC PNIGECWGGG 120
EYATATATIM LMGDTCTRGC RFCSVKTARN PPPLDANEPD NTAKAIAEWG LDYVVLTSVD 180
RDDVADGGAE HIAKTVSCLK ERNPKILVEC LTPDFRGDLR AVEKVALSGL DVYAHNVETV 240
PELQRKVRDP RANFDQSLRV LRHAKEVQPD VVSKTSIMLG LGETDEQVYA TLKALRAADV 300
DCLTLGQYMQ PTKRHLKVEE YVTPEKFKYW EKVGNELGFL YTASGPLVRS SYKAGEFFLK 360
NLVARRKTKA SKV 373 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:HAMAP.
 GO:0016992; F:lipoate synthase activity; IGI:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006954; P:inflammatory response; IMP:MGI.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0009249; P:protein lipoylation; IEA:HAMAP.
 GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
 GO:0006979; P:response to oxidative stress; IMP:MGI. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR006638; Elp3/MiaB/NifB.
 IPR003698; Lipoyl_synth.
 IPR007197; rSAM. 
Pfam
 PF04055; Radical_SAM 
SMART
 SM00729; Elp3 
PROSITE
  
PRINTS