UniProt Accession

 GILT_MOUSE; Q9ESY9; G3X911; Q3U0F9; Q9EP56 

Genbank Protein ID

 AF309649; AF309650; AF290973; AK156914; AC162446; CH466569; BC054852 

Genbank Nucleotide ID

 AAG34681.1; AAG34682.1; AAG00598.1; BAE33895.1; EDL28872.1; AAH54852.1 

Protein Name

 Gamma-interferon-inducible lysosomal thiol reductase 

Protein Synonyms/Alias

 Gamma-interferon-inducible protein IP-30; Lysosomal thiol reductase IP30 

Gene Name

 Ifi30 

Gene Synonyms/Alias

 Gilt; Ip30 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
133	VEACLLDKLEKEAAF	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. 

Sequence Annotation

 CARBOHYD 92 92 N-linked (GlcNAc...) (Potential).
 CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
 DISULFID 69 72 Redox-active (By similarity).  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Immunity; Lysosome; Oxidoreductase; Redox-active center; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0015036; F:disulfide oxidoreductase activity; TAS:MGI.
 GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IMP:UniProtKB.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IMP:MGI.
 GO:0048147; P:negative regulation of fibroblast proliferation; IMP:MGI.
 GO:0050821; P:protein stabilization; IMP:MGI. 

Interpro

 IPR004911; Interferon-induced_GILT. 

Pfam

 PF03227; GILT 

SMART

  

PROSITE

  

PRINTS