UniProt Accession

 DBNL_RAT; Q9JHL4; Q9JM66; Q9JM67; Q9JM74 

Genbank Protein ID

 AB038364; AB038365; AB039818; AB039819; AB009346; BC072483 

Genbank Nucleotide ID

 BAA90866.1; BAA90867.1; BAA92708.1; BAA92709.1; BAA90819.1; AAH72483.1 

Protein Name

 Drebrin-like protein 

Protein Synonyms/Alias

 Actin-binding protein 1; Abp1; SH3 domain-containing protein 7 

Gene Name

 Dbnl 

Gene Synonyms/Alias

 Sh3p7 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
70	MYAFCRVKDPNSGLP	acetylation	[1]
176	SEIKRVGKDNFWAKA	acetylation	[1]
288	VSSSQPGKLRSPFLQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. 

Sequence Annotation

 DOMAIN 2 133 ADF-H.
 DOMAIN 377 436 SH3.
 MOD_RES 176 176 N6-acetyllysine (By similarity).
 MOD_RES 277 277 Phosphoserine (By similarity).
 MOD_RES 278 278 Phosphothreonine (By similarity).
 MOD_RES 291 291 Phosphoserine (By similarity).
 MOD_RES 296 296 N6-acetyllysine (By similarity).
 MOD_RES 299 299 Phosphothreonine (By similarity).
 MOD_RES 340 340 Phosphotyrosine (By similarity).
 MOD_RES 350 350 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Actin-binding; Adaptive immunity; Alternative splicing; Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endocytosis; Golgi apparatus; Immunity; Membrane; Phosphoprotein; Reference proteome; SH3 domain; Synapse; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 436 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; ISS:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0030027; C:lamellipodium; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0002102; C:podosome; ISS:UniProtKB.
 GO:0014069; C:postsynaptic density; IDA:RGD.
 GO:0001726; C:ruffle; ISS:UniProtKB.
 GO:0051015; F:actin filament binding; ISS:UniProtKB.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
 GO:0071800; P:podosome assembly; ISS:UniProtKB.
 GO:0016601; P:Rac protein signal transduction; ISS:UniProtKB.
 GO:0007416; P:synapse assembly; ISS:UniProtKB. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR001452; SH3_domain. 

Pfam

 PF00241; Cofilin_ADF
 PF00018; SH3_1 

SMART

 SM00102; ADF
 SM00326; SH3 

PROSITE

 PS51263; ADF_H
 PS50002; SH3 

PRINTS