CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042282
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone H4 
Protein Synonyms/Alias
  
Gene Name
 HIST1H4E 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
6**MSGRGKGGKGLGKacetylation[1]
9SGRGKGGKGLGKGGAacetylation[1]
13KGGKGLGKGGAKRHRacetylation[1]
17GLGKGGAKRHRKVLRacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019
Functional Description
 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 
Sequence Annotation
  
Keyword
 Chromosome; Complete proteome; DNA-binding; Nucleosome core; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 103 AA 
Protein Sequence
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK 60
VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG 103 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0045653; P:negative regulation of megakaryocyte differentiation; IEA:Compara.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 
Interpro
 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 
Pfam
 PF00125; Histone 
SMART
 SM00417; H4 
PROSITE
 PS00047; HISTONE_H4 
PRINTS
 PR00623; HISTONEH4.