UniProt Accession

 COX15_HUMAN; Q7KZN9; A8K6I9; O60556; O75878; Q5TD00; Q5TD01; Q7Z3Q3; Q9NTN0 

Genbank Protein ID

 AF026850; AF044323; BT007129; AK291654; BX537557; AL133353; AL133353; CH471066; BC002382; BC013403; BC078161 

Genbank Nucleotide ID

 AAD08639.1; AAD08646.1; AAP35793.1; BAF84343.1; CAD97781.1; CAB88197.1; CAB88198.1; EAW49857.1; AAH02382.3; AAH13403.1; AAH78161.1 

Protein Name

 Cytochrome c oxidase assembly protein COX15 homolog 

Protein Synonyms/Alias

  

Gene Name

 COX15 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	GTVSLPSKAAERVVG	ubiquitination	[1, 2, 3]
109	WHLIKEMKPPTSQEE	ubiquitination	[2]
131	YQQFPEFKILNHDMT	ubiquitination	[2]
209	VKSGLEEKSDSHDIP	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be involved in the biosynthesis of heme A. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Leigh syndrome; Membrane; Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 410 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005746; C:mitochondrial respiratory chain; TAS:UniProtKB.
 GO:0004129; F:cytochrome-c oxidase activity; TAS:UniProtKB.
 GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
 GO:0006784; P:heme a biosynthetic process; IGI:HGNC.
 GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IC:HGNC.
 GO:0008535; P:respiratory chain complex IV assembly; IMP:HGNC.
 GO:0007585; P:respiratory gaseous exchange; TAS:UniProtKB. 

Interpro

 IPR003780; HemeA_syn.
 IPR023754; HemeA_Synthase_type2.
 IPR009003; Trypsin-like_Pept_dom. 

Pfam

 PF02628; COX15-CtaA 

SMART

  

PROSITE

  

PRINTS