CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014433
UniProt Accession
Genbank Protein ID
 U58885 
Genbank Nucleotide ID
Protein Name
 Endophilin-A2 
Protein Synonyms/Alias
 Endophilin-2; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3p8 
Gene Name
 Sh3gl1 
Gene Synonyms/Alias
 Sh3d2b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12GLKKQFYKASQLVSEacetylation[1]
20ASQLVSEKVGGAEGTacetylation[1]
76TMLNTVSKIRGQVKNacetylation[1]
76TMLNTVSKIRGQVKNubiquitination[2]
102ECMVRHGKELGGESNubiquitination[2]
239ILEELADKLKRRVREubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). 
Sequence Annotation
 DOMAIN 18 249 BAR.
 DOMAIN 306 365 SH3.
 REGION 1 21 Membrane-binding amphipathic helix (By
 REGION 60 87 Required for dimerization upon membrane
 REGION 218 254 Interaction with ARC (By similarity).
 MOD_RES 288 288 Phosphoserine.  
Keyword
 Cell junction; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endocytosis; Endosome; Lipid-binding; Membrane; Phosphoprotein; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 368 AA 
Protein Sequence
MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKDMEKKV DVTSKAVAEV LVRTIEYLQP 60
NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMVRH GKELGGESNF GDALLDAGES 120
MKRLAEVKDS LDIEVKQNFI DPLQNLCDKD LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD 180
EELRQALEKF EESKEVAETS MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILEELADKL 240
KRRVREASSR PKREFKPRPR EPFELGELEQ PNGGFPCAPA PKITASSSFR SSDKPIRMPS 300
KSMPPLDQPS CKALYDFEPE NDGELGFREG DLITLTNQID ENWYEGMLHG QSGFFPLSYV 360
QVLVPLPQ 368 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW. 
Interpro
 IPR027267; AH/BAR-dom.
 IPR004148; BAR_dom.
 IPR001452; SH3_domain. 
Pfam
 PF03114; BAR
 PF00018; SH3_1 
SMART
 SM00721; BAR
 SM00326; SH3 
PROSITE
 PS51021; BAR
 PS50002; SH3 
PRINTS
 PR00452; SH3DOMAIN.