| Tag | Content |
|---|
| CPLM ID | CPLM-017743 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tudor domain-containing protein 7 |
Protein Synonyms/Alias | PCTAIRE2-binding protein; Tudor repeat associator with PCTAIRE-2; Trap |
Gene Name | TDRD7 |
Gene Synonyms/Alias | PCTAIRE2BP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 576 | SLSFQATKCKLAGLE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. |
Sequence Annotation | DOMAIN 3 76 HTH OST-type 1.
DOMAIN 233 302 HTH OST-type 2.
DOMAIN 337 406 HTH OST-type 3.
DOMAIN 513 570 Tudor 1.
DOMAIN 703 760 Tudor 2.
REGION 861 1098 Interacts with CDK17 (By similarity).
REGION 893 1098 Interacts with CABLES1 (By similarity). |
Keyword | 3D-structure; Alternative splicing; Cataract; Complete proteome; Cytoplasm; Differentiation; Disease mutation; Polymorphism; Reference proteome; Repeat; RNA-binding; Spermatogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1098 AA |
Protein Sequence | MLEGDLVSKM LRAVLQSHKN GVALPRLQGE YRSLTGDWIP FKQLGFPTLE AYLRSVPAVV 60
RIETSRSGEI TCYAMACTET ARIAQLVARQ RSSKRKTGRQ VNCQMRVKKT MPFFLEGKPK 120
ATLRQPGFAS NFSVGKKPNP APLRDKGNSV GVKPDAEMSP YMLHTTLGNE AFKDIPVQRH 180
VTMSTNNRFS PKASLQPPLQ MHLSRTSTKE MSDNLNQTVE KPNVKPPASY TYKMDEVQNR 240
IKEILNKHNN GIWISKLPHF YKELYKEDLN QGILQQFEHW PHICTVEKPC SGGQDLLLYP 300
AKRKQLLRSE LDTEKVPLSP LPGPKQTPPL KGCPTVMAGD FKEKVADLLV KYTSGLWASA 360
LPKAFEEMYK VKFPEDALKN LASLSDVCSI DYISGNPQKA ILYAKLPLPT DKIQKDAGQA 420
HGDNDIKAMV EQEYLQVEES IAESANTFME DITVPPLMIP TEASPSVLVV ELSNTNEVVI 480
RYVGKDYSAA QELMEDEMKE YYSKNPKITP VQAVNVGQLL AVNAEEDAWL RAQVISTEEN 540
KIKVCYVDYG FSENVEKSKA YKLNPKFCSL SFQATKCKLA GLEVLSDDPD LVKVVESLTC 600
GKIFAVEILD KADIPLVVLY DTSGEDDINI NATCLKAICD KSLEVHLQVD AMYTNVKVTN 660
ICSDGTLYCQ VPCKGLNKLS DLLRKIEDYF HCKHMTSECF VSLPFCGKIC LFHCKGKWLR 720
VEITNVHSSR ALDVQFLDSG TVTSVKVSEL REIPPRFLQE MIAIPPQAIK CCLADLPQSI 780
GMWTPDAVLW LRDSVLNCSD CSIKVTKVDE TRGIAHVYLF TPKNFPDPHR SINRQITNAD 840
LWKHQKDVFL SAISSGADSP NSKNGNMPMS GNTGENFRKN LTDVIKKSMV DHTSAFSTEE 900
LPPPVHLSKP GEHMDVYVPV ACHPGYFVIQ PWQEIHKLEV LMEEMILYYS VSEERHIAVE 960
KDQVYAAKVE NKWHRVLLKG ILTNGLVSVY ELDYGKHELV NIRKVQPLVD MFRKLPFQAV 1020
TAQLAGVKCN QWSEEASMVF RNHVEKKPLV ALVQTVIENA NPWDRKVVVY LVDTSLPDTD 1080
TWIHDFMSEY LIELSKVN 1098 |
Gene Ontology | GO:0033391; C:chromatoid body; ISS:UniProtKB. GO:0005759; C:mitochondrial matrix; IEA:Compara. GO:0043186; C:P granule; IEA:Compara. GO:0003729; F:mRNA binding; IDA:UniProtKB. GO:0007281; P:germ cell development; IEA:Compara. GO:0070306; P:lens fiber cell differentiation; IMP:UniProtKB. GO:0002089; P:lens morphogenesis in camera-type eye; IMP:UniProtKB. GO:0010608; P:posttranscriptional regulation of gene expression; IMP:UniProtKB. GO:0007283; P:spermatogenesis; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |