UniProt Accession

 XERC_ECOLI; P0A8P6; P22885; Q2M8B7 

Genbank Protein ID

 M38257; M87049; U00096; AP009048 

Genbank Nucleotide ID

 AAA24763.1; AAA67607.1; AAC76814.1; BAE77489.1 

Protein Name

 Tyrosine recombinase XerC 

Protein Synonyms/Alias

  

Gene Name

 xerC 

Gene Synonyms/Alias

 b3811; JW3784 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
210	DDALFLSKLGKRISA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or psi) sites. In the complex XerC specifically exchanges the top DNA strands (By similarity). 

Sequence Annotation

 ACT_SITE 148 148 By similarity.
 ACT_SITE 172 172 By similarity.
 ACT_SITE 240 240 By similarity.
 ACT_SITE 243 243 By similarity.
 ACT_SITE 266 266 By similarity.
 ACT_SITE 275 275 O-(3'-phospho-DNA)-tyrosine intermediate.  

Keyword

 Cell cycle; Cell division; Chromosome partition; Complete proteome; Cytoplasm; Direct protein sequencing; DNA integration; DNA recombination; DNA-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0048476; C:Holliday junction resolvase complex; IDA:EcoCyc.
 GO:0003677; F:DNA binding; IDA:EcoliWiki.
 GO:0009037; F:tyrosine-based site-specific recombinase activity; IDA:EcoliWiki.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007059; P:chromosome segregation; IEA:HAMAP.
 GO:0006276; P:plasmid maintenance; IMP:EcoliWiki.
 GO:0042150; P:plasmid recombination; IMP:EcoliWiki.
 GO:0071139; P:resolution of recombination intermediates; IDA:EcoliWiki.
 GO:0006313; P:transposition, DNA-mediated; IEA:HAMAP. 

Interpro

 IPR011010; DNA_brk_join_enz.
 IPR013762; Integrase-like_cat-core.
 IPR002104; Integrase_catalytic.
 IPR010998; Integrase_Lambda-type_N.
 IPR023109; Integrase_recombinase_N.
 IPR004107; Integrase_SAM-like_N.
 IPR011931; Recomb_XerC.
 IPR023009; Tyrosine_recombinase_XerC/XerD. 

Pfam

 PF02899; Phage_integr_N
 PF00589; Phage_integrase 

SMART

  

PROSITE

  

PRINTS