UniProt Accession

 TR112_YEAST; P53738; D6W1M1 

Genbank Protein ID

 Z71661; BK006947 

Genbank Nucleotide ID

 CAA96327.1; DAA10587.1 

Protein Name

 Multifunctional methyltransferase subunit TRM112 

Protein Synonyms/Alias

 eRF1 methyltransferase subunit TRM112; eRF1 MTase subunit TRM112; tRNA methyltransferase 112 

Gene Name

 TRM112 

Gene Synonyms/Alias

 YNR046W; N3445 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
2	******MKFLTTNFL	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Together with MTQ2, required for the methylation of eRF1 on 'Gln-182'. Together with TRM11, required for the formation of 2-methylguanosine at position 10 in tRNA. Probably has additional functions. 

Sequence Annotation

 DOMAIN 2 131 TRM112.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 135 AA 

Protein Sequence

Gene Ontology

 GO:0035657; C:eRF1 methyltransferase complex; IPI:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0043528; C:tRNA (m2G10) methyltransferase complex; IPI:SGD.
 GO:0000470; P:maturation of LSU-rRNA; IMP:SGD.
 GO:0030490; P:maturation of SSU-rRNA; IMP:SGD.
 GO:0018364; P:peptidyl-glutamine methylation; IDA:SGD.
 GO:0070476; P:rRNA (guanine-N7)-methylation; IMP:SGD.
 GO:0030488; P:tRNA methylation; IMP:SGD. 

Interpro

 IPR005651; UPF0434/Trm112. 

Pfam

 PF03966; Trm112p 

SMART

  

PROSITE

  

PRINTS