UniProt Accession

 SPSB4_HUMAN; Q96A44 

Genbank Protein ID

 AF403029; AK056367; BC008324 

Genbank Nucleotide ID

 AAL57348.1; BAB71165.1; AAH08324.1 

Protein Name

 SPRY domain-containing SOCS box protein 4 

Protein Synonyms/Alias

 SSB-4 

Gene Name

 SPSB4 

Gene Synonyms/Alias

 SSB4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	QKLSGSLKSVEVREP	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 

Sequence Annotation

 DOMAIN 34 233 B30.2/SPRY.
 DOMAIN 234 273 SOCS box.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 273 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR001496; SOCS_C.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 

Pfam

 PF07525; SOCS_box
 PF00622; SPRY 

SMART

 SM00969; SOCS_box
 SM00449; SPRY 

PROSITE

 PS50188; B302_SPRY
 PS50225; SOCS 

PRINTS