UniProt Accession

 J3KTE4_HUMAN; J3KTE4 

Genbank Protein ID

 AC004408; CH471152 

Genbank Nucleotide ID

 EAW60566.1 

Protein Name

 Ribosomal protein L19 

Protein Synonyms/Alias

  

Gene Name

 RPL19 

Gene Synonyms/Alias

 hCG_31402 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	SVLRCGKKKVWLDPN	ubiquitination	[1, 2]
19	VLRCGKKKVWLDPNE	ubiquitination	[2, 3, 4, 5, 6]
41	NSRQQIRKLIKDGLI	ubiquitination	[2, 3, 6, 7]
44	QQIRKLIKDGLIIRK	ubiquitination	[1, 2, 3, 4, 5, 6, 7]
51	KDGLIIRKPVTVHSR	ubiquitination	[1, 5]
78	GRHMGIGKRKGTANA	acetylation	[6]
90	ANARMPEKVTWMRRM	ubiquitination	[1, 2, 3, 4, 5, 6]
124	MYHSLYLKVKGNVFK	ubiquitination	[2, 5, 7]
126	HSLYLKVKGNVFKNK	ubiquitination	[2, 4, 5, 6]
131	KVKGNVFKNKRILME	ubiquitination	[4]
142	ILMEHIHKLKADKAR	ubiquitination	[2, 3, 4, 6]
144	MEHIHKLKADKARKK	ubiquitination	[2, 6]
150	LKADKARKKLLADQA	ubiquitination	[1, 2, 6, 8]
151	KADKARKKLLADQAE	ubiquitination	[1, 2, 3, 4, 6, 8]
178	REERLQAKKEEIIKT	acetylation	[6, 9]
178	REERLQAKKEEIIKT	ubiquitination	[1, 2, 4, 5, 6]
179	EERLQAKKEEIIKTL	ubiquitination	[2, 3, 4, 5, 6]
184	AKKEEIIKTLSKEEE	acetylation	[9]
184	AKKEEIIKTLSKEEE	ubiquitination	[1, 2, 3, 4, 5, 6]
188	EIIKTLSKEEETKK*	acetylation	[6, 10]
188	EIIKTLSKEEETKK*	ubiquitination	[4, 5]
193	LSKEEETKK******	ubiquitination	[1, 4]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [8] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [9] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [10] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0003735; F:structural constituent of ribosome; IEA:Compara.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR027547; Ribosomal_L19/L19e.
 IPR023638; Ribosomal_L19/L19e_CS.
 IPR000196; Ribosomal_L19/L19e_dom.
 IPR015972; Ribosomal_L19/L19e_dom1.
 IPR015974; Ribosomal_L19/L19e_dom3. 

Pfam

 PF01280; Ribosomal_L19e 

SMART

  

PROSITE

 PS00526; RIBOSOMAL_L19E 

PRINTS