CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013091
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Microtubule-associated tumor suppressor candidate 2 homolog 
Protein Synonyms/Alias
 Cardiac zipper protein; Microtubule plus-end tracking protein TIP150; Tracking protein of 150 kDa 
Gene Name
 Mtus2 
Gene Synonyms/Alias
 Cazip; Kiaa0774; Tip150 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1018DALAVSTKHFFGKSEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip (By similarity). 
Sequence Annotation
 REGION 626 964 Mediates interaction with MAPRE1 (By
 REGION 786 1134 Localization to the growing distal tip of
 REGION 786 874 Sufficient for interaction with KIF2C (By  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1353 AA 
Protein Sequence
MSVPLAPKKS CFGQLRDHRE GAKNNNESIL RTGDTNANQI MLEVSSSCDE AKSRDLDDEL 60
GNSNLSRPQY HSHFQKEPLH LQGFGKGSQA GSTSQRESQA SLTVHRQLSE EHAVKRGALQ 120
APQCVQGPSL SSWRNAVGQA SPEASAKKDA EIPRHIPKDK LAKTLDNEEL KRASSCSAAA 180
GSVPPTDLQP VQLDTLGPQD HVPARGEGPQ RTPASHSPGK GFSPGEGTSE GNSVYLPKPS 240
TSEAKGSSPS DTKMEGPHGL DVYNERITHA ELTPSSASAS KENPGLRHPE VCLGQGTGKS 300
KVELKSVQPR NEEGLTSAQA QGPGCHEERS MSPVERQELL EKAYREATSQ GNSSHRQLGV 360
RRGSSLEEMT GVSAGVEGSQ QATPTLSAAP AGEAGTRLTG KMSAGVGRMA RETASGQTAP 420
DVGQAAPVRR DPTESVPSEV SGEERRLGSG NSGSTKLLAS GPSAGGSRTD TSGLLSPRGS 480
NLEARKGKEM VAENRNLLEN AAQTDNTPAG VDSAFSTPAP LLHPETTVNS SHHPTPPGSS 540
SQELGVFSGD TGSPSVASPP TDGGQVLNTS PKVPDRTTCS SGIPKPPTHP KDTPSSQEAR 600
EKLETEKMEE RAEAKPILMP KPKHVRPKII TYIRRNPQAL SQGDASLVPV GLPYAPPTCG 660
MPLPQEEKAA SRDLQPSANM YEKLKPDLQK PRVFPSGLMV SGIKPPAHHF SQMSEKFLQE 720
VADHPGKEEF CSPPYTHYEV PPTFYRSAML LKPQLGLGAM SRLPSTKSRI LIASQRSSAS 780
AIHPPGSLTT AASFYGSDPS DLKKASNSNA AKASLPKSGL RPPGYSRLPA AKLAAFGFVR 840
SSSISAVPSS QSLDSVQPEQ SRPVTRSTFG NEEQAPLKQA LPSKDTPKGA GRAAPASSSN 900
ATTPRRSLLP APKSTSTPAG AKKELQKDPE AKKPAVSSPK RTASAATKPH SPGYPKQRTS 960
APRNEFPPKP DLQAREAERQ LAQRLRDRCE WQARQLGLAR RELKKAIQGF DALAVSTKHF 1020
FGKSERALAK EKELSIELAN IRDEVAFNTA KCEKLQKEKE TLERRFEEEL RRLGWQQQAE 1080
VQELQERLQQ QFQAESARLQ AEHQDQLLRM RCQHQEQVED ITASHEAALL EMENNHTVAI 1140
TILQDDHDHK VQELMSTHEF EKKELEENFE KLRLTLQDQV DTLTFQSQSL RDRARRFEEA 1200
LRKTTEEQLE IALAPYQHLE EDMQSLKQVL EMKNQQIHLQ EKKIIELEKL VEKNIILEER 1260
IQVLQQQNED LKARIDQNTV VTRQLSEENA NLQEYVEKET QEKKRLSRTN EELLWKLQTG 1320
DPTSPIKLSP TSPVYRGSSS GPSSPARVST TPR 1353 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005881; C:cytoplasmic microtubule; IEA:Compara.
 GO:0008017; F:microtubule binding; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS