CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022023
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Poliovirus receptor-related protein 3 
Protein Synonyms/Alias
 CDw113; Nectin-3; CD113 
Gene Name
 PVRL3 
Gene Synonyms/Alias
 PRR3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
451IPPSDMQKESQIDVLubiquitination[1, 2]
471DSYPDSVKKENKNPVubiquitination[1, 2]
492DYLEEPEKTQWNNVEubiquitination[1]
515MDYYEDLKMGMKFVSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. 
Sequence Annotation
 DOMAIN 59 165 Ig-like V-type.
 DOMAIN 170 258 Ig-like C2-type 1.
 DOMAIN 269 354 Ig-like C2-type 2.
 CARBOHYD 73 73 N-linked (GlcNAc...).
 CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
 CARBOHYD 125 125 N-linked (GlcNAc...).
 CARBOHYD 186 186 N-linked (GlcNAc...).
 CARBOHYD 222 222 N-linked (GlcNAc...).
 CARBOHYD 331 331 N-linked (GlcNAc...).
 DISULFID 78 148 By similarity.
 DISULFID 193 246 By similarity.
 DISULFID 291 338 By similarity.  
Keyword
 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 549 AA 
Protein Sequence
MARTLRPSPL CPGGGKAQLS SASLLGAGLL LQPPTPPPLL LLLFPLLLFS RLCGALAGPI 60
IVEPHVTAVW GKNVSLKCLI EVNETITQIS WEKIHGKSSQ TVAVHHPQYG FSVQGEYQGR 120
VLFKNYSLND ATITLHNIGF SDSGKYICKA VTFPLGNAQS STTVTVLVEP TVSLIKGPDS 180
LIDGGNETVA AICIAATGKP VAHIDWEGDL GEMESTTTSF PNETATIISQ YKLFPTRFAR 240
GRRITCVVKH PALEKDIRYS FILDIQYAPE VSVTGYDGNW FVGRKGVNLK CNADANPPPF 300
KSVWSRLDGQ WPDGLLASDN TLHFVHPLTF NYSGVYICKV TNSLGQRSDQ KVIYISDPPT 360
TTTLQPTIQW HPSTADIEDL ATEPKKLPFP LSTLATIKDD TIATIIASVV GGALFIVLVS 420
VLAGIFCYRR RRTFRGDYFA KNYIPPSDMQ KESQIDVLQQ DELDSYPDSV KKENKNPVNN 480
LIRKDYLEEP EKTQWNNVEN LNRFERPMDY YEDLKMGMKF VSDEHYDENE DDLVSHVDGS 540
VISRREWYV 549 
Gene Ontology
 GO:0043296; C:apical junction complex; IEA:Compara.
 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; ISS:HGNC.
 GO:0042803; F:protein homodimerization activity; ISS:HGNC.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0009566; P:fertilization; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; ISS:HGNC.
 GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Compara.
 GO:0060042; P:retina morphogenesis in camera-type eye; IEA:Compara. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 
Pfam
 PF08205; C2-set_2
 PF07686; V-set 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS