CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005483
UniProt Accession
Genbank Protein ID
 M86567 
Genbank Nucleotide ID
Protein Name
 Gamma-aminobutyric acid receptor subunit alpha-2 
Protein Synonyms/Alias
 GABA(A) receptor subunit alpha-2 
Gene Name
 Gabra2 
Gene Synonyms/Alias
 Gabra-2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
389PVLSTISKSATTPEPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
Sequence Annotation
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
 DISULFID 166 180 By similarity.  
Keyword
 Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 451 AA 
Protein Sequence
MKTKLSTCNV WSLLLVLLVW DPVRLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG 60
LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNLMASK 120
IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC 180
PLKFGSYAYT TSEVTYIWTY NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM 240
TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 300
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKKKEKGSV 360
MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM 420
SRIVFPVLFG TFNLVYWATY LNREPVLGVS P 451 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0030285; C:integral to synaptic vesicle membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0008503; F:benzodiazepine receptor activity; IEA:Compara.
 GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
 GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
 GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
 GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:Compara.
 GO:0006836; P:neurotransmitter transport; IEA:Compara.
 GO:0001505; P:regulation of neurotransmitter levels; IEA:Compara. 
Interpro
 IPR006028; GABAA_rcpt.
 IPR001390; GABAAa_rcpt.
 IPR005432; GABBAa2_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 
Pfam
 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 
SMART
  
PROSITE
 PS00236; NEUROTR_ION_CHANNEL 
PRINTS
 PR01079; GABAARALPHA.
 PR01615; GABAARALPHA2.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.