CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020305
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caspase recruitment domain-containing protein 6 
Protein Synonyms/Alias
  
Gene Name
 CARD6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
307KVLPDFVKQFSLDRGubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in apoptosis. 
Sequence Annotation
 DOMAIN 3 94 CARD.  
Keyword
 Apoptosis; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1037 AA 
Protein Sequence
MATESTPSEI IERERKKLLE ILQHDPDSIL DTLTSRRLIS EEEYETLENV TDLLKKSRKL 60
LILVQKKGEA TCQHFLKCLF STFPQSAAIC GLRHEVLKHE NTVPPQSMGA SSNSEDAFSP 120
GIKQPEAPEI TVFFSEKEHL DLETSEFFRD KKTSYRETAL SARKNEKEYD TPEVTLSYSV 180
EKVGCEVPAT ITYIKDGQRY EELDDSLYLG KEEYLGSVDT PEDAEATVEE EVYDDPEHVG 240
YDGEEDFENS ETTEFSGEEP SYEGSETSLS LEEEQEKSIE ERKKVFKDVL LCLNMDRSRK 300
VLPDFVKQFS LDRGCKWTPE SPGDLAWNFL MKVQARDVTA RDSILSHKVL DEDSKEDLLA 360
GVENLEIRDI QTINPLDVLC ATMLCSDSSL QRQVMSNMYQ CQFALPLLLP DAENNKSILM 420
LGAMKDIVKK QSTQFSGGPT EDTEKFLTLM KMPVISFVRL GYCSFSKSRI LNTLLSPAQL 480
KLHKIFLHQD LPLLVLPRQI SDGLVEITWC FPDSDDRKEN PFFQKPVALA NLRGNLESFW 540
TQFGFLMEVS SAVFFFTDCL GEKEWDLLMF LGEAAIERCY FVLSSQARES EEAQIFQRIL 600
NLKPAQLLFW ERGDAGDRRK NMEGLQAALQ EVMFSSCLRC VSVEDMAALA RELGIQVDED 660
FENTQRIQVS SGENMAGTAE GEGQQRHSQL KSSSKSQALM PIQEPGTQCE LSQNLQNLYG 720
TPVFRPVLEN SWLFPTRIGG NFNHVSLKAS WVMGRPFGSE QRPKWFHPLP FQNAGAQGRG 780
KSFGIQSFHP QIFYSGERFM KFSRVARGCH SNGTFGRLPR PICQHVQACP ERPQMMGTLE 840
RSRAVASKIG HSYSLDSQPA RAVGKPWPQQ ACTRVTELTE ATGKLIRTSH IGKPHPQSFQ 900
PAAATQKLRP ASQQGVQMKT QGGASNPALQ IGSHPMCKSS QFKSDQSNPS TVKHSQPKPF 960
HSVPSQPKSS QTKSCQSQPS QTKPSPCKST QPKPSQPWPP QSKPSQPRPP QPKSSSTNPS 1020
QAKAHHSKAG QKRGGKH 1037 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro. 
Interpro
 IPR001315; CARD.
 IPR011029; DEATH-like_dom. 
Pfam
 PF00619; CARD 
SMART
 SM00114; CARD 
PROSITE
 PS50209; CARD 
PRINTS