CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator RpiR 
Protein Synonyms/Alias
 Als operon repressor 
Gene Name
 rpiR 
Gene Synonyms/Alias
 alsR; yjcY; b4089; JW4050 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
69AMIVKVSKLLGFSGFacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Regulatory protein involved in rpiB gene repression. Also involved in als operon repression. 
Sequence Annotation
 DOMAIN 14 90 HTH rpiR-type.
 DOMAIN 134 274 SIS.
 DNA_BIND 50 69 H-T-H motif (Potential).  
Keyword
 Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 296 AA 
Protein Sequence
MSQSEFDSAL PNGIGLAPYL RMKQEGMTEN ESRIVEWLLK PGNLSCAPAI KDVAEALAVS 60
EAMIVKVSKL LGFSGFRNLR SALEDYFSQS EQVLPSELAF DEAPQDVVNK VFNITLRTIM 120
EGQSIVNVDE IHRAARFFYQ ARQRDLYGAG GSNAICADVQ HKFLRIGVRC QAYPDAHIMM 180
MSASLLQEGD VVLVVTHSGR TSDVKAAVEL AKKNGAKIIC ITHSYHSPIA KLADYIICSP 240
APETPLLGRN ASARILQLTL LDAFFVSVAQ LNIEQANINM QKTGAIVDFF SPGALK 296 
Gene Ontology
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000281; HTH_RpiR.
 IPR001347; SIS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01418; HTH_6
 PF01380; SIS 
SMART
  
PROSITE
 PS51071; HTH_RPIR
 PS51464; SIS 
PRINTS