CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035765
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chaperonin subunit 8 (Theta) (Predicted), isoform CRA_a 
Protein Synonyms/Alias
 Protein Cct8 
Gene Name
 Cct8 
Gene Synonyms/Alias
 Cct8_predicted; rCG_58706 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
7*MALHVPKAPGFAQMubiquitination[1]
16PGFAQMLKDGAKHFSacetylation[2]
62MVINRLEKLFVTNDAacetylation[2]
62MVINRLEKLFVTNDAubiquitination[1]
224VLHGMVFKKETEGDVacetylation[2]
235EGDVTSVKDAKIAVYacetylation[2]
235EGDVTSVKDAKIAVYubiquitination[1]
318MLVRLNSKWDLRRLCacetylation[2]
400DDGVNTFKVLTRDKRacetylation[2]
466KANEVISKLYSVHQEacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 548 AA 
Protein Sequence
MALHVPKAPG FAQMLKDGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN GMNKMVINRL 60
EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG TNFVLVFAGA LLELAEELLR 120
IGLSVSEVIT GYEIACKKAH EILPDLVCCS AKNLRDVDEV SSLLRTSIMS KQYGSEEFLA 180
KLISQACVSI FPDSGNFNVD NIRVCKILGS GVYSSSVLHG MVFKKETEGD VTSVKDAKIA 240
VYSCPFDGMI TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIAGTGANV IVTGGKVADM 300
ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPKLTPPV LEEMGHCDSV YLSEVGDTQV 360
VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK VLTRDKRLVP GGGATEIELA 420
KQITSYGETC PGLEQYAIKK FAEAFEAIPR ALAENSGVKA NEVISKLYSV HQEGNKNVGL 480
DIEAEVPAVK DMLEASILDT YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK 540
DWDDDQND 548 
Gene Ontology
 GO:0016235; C:aggresome; IEA:Compara.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012721; Chap_CCT_theta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.